Rodgers L W, Stringer S P, Mendenhall W M, Parsons J T, Cassisi N J, Million R R
Department of Otolaryngology, University of Florida College of Medicine, Gainesville.
Head Neck. 1993 Jan-Feb;15(1):16-9. doi: 10.1002/hed.2880150104.
Between 1964 and 1987, 194 patients with previously untreated squamous cell carcinoma of the floor of mouth were managed at the University of Florida. A retrospective analysis was undertaken in order to evaluate the treatment results and associated complication rates. Surgery or irradiation alone was found to result in similar local control rates for stage I and II lesions, whereas more advanced tumors had better local control rates with a combination of surgery and irradiation. Radiotherapy had a higher incidence of minor and moderate complications, whereas a greater number of severe complications occurred after surgery. We recommend surgery for early lesions due to the lower overall incidence of associated complications. Despite a higher risk of severe complications, combination therapy is recommended for more advanced lesions due to improved local control as compared to single modality therapy.
1964年至1987年间，佛罗里达大学对194例未经治疗的口底鳞状细胞癌患者进行了治疗。为了评估治疗结果及相关并发症发生率，进行了一项回顾性分析。结果发现，对于I期和II期病变，单独手术或放疗的局部控制率相似，而对于更晚期的肿瘤，手术和放疗联合应用的局部控制率更高。放疗的轻度和中度并发症发生率较高，而手术后发生的严重并发症数量更多。由于相关并发症的总体发生率较低，我们建议对早期病变采用手术治疗。尽管严重并发症的风险较高，但由于与单一治疗方式相比，联合治疗可改善局部控制，因此建议对更晚期病变采用联合治疗。
