• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

功能连接性:大型(正电子发射断层扫描)数据集的主成分分析

Functional connectivity: the principal-component analysis of large (PET) data sets.

作者信息

Friston K J, Frith C D, Liddle P F, Frackowiak R S

机构信息

MRC Cyclotron Unit, Hammersmith Hospital, London, U.K.

出版信息

J Cereb Blood Flow Metab. 1993 Jan;13(1):5-14. doi: 10.1038/jcbfm.1993.4.

DOI:10.1038/jcbfm.1993.4
PMID:8417010
Abstract

The distributed brain systems associated with performance of a verbal fluency task were identified in a nondirected correlational analysis of neurophysiological data obtained with positron tomography. This analysis used a recursive principal-component analysis developed specifically for large data sets. This analysis is interpreted in terms of functional connectivity, defined as the temporal correlation of a neurophysiological index measured in different brain areas. The results suggest that the variance in neurophysiological measurements, introduced experimentally, was accounted for by two independent principal components. The first, and considerably larger, highlighted an intentional brain system seen in previous studies of verbal fluency. The second identified a distributed brain system including the anterior cingulate and Wernicke's area that reflected monotonic time effects. We propose that this system has an attentional bias.

摘要

在对通过正电子断层扫描获得的神经生理数据进行无向相关分析时,确定了与言语流畅性任务表现相关的分布式脑系统。该分析使用了专门为大型数据集开发的递归主成分分析。这种分析是根据功能连接性来解释的,功能连接性被定义为在不同脑区测量的神经生理指标的时间相关性。结果表明,实验引入的神经生理测量中的方差由两个独立的主成分解释。第一个,也是大得多的一个,突出了先前言语流畅性研究中发现的一个有意的脑系统。第二个确定了一个包括前扣带回和韦尼克区的分布式脑系统,该系统反映了单调的时间效应。我们认为这个系统存在注意力偏差。

相似文献

1
Functional connectivity: the principal-component analysis of large (PET) data sets.功能连接性:大型(正电子发射断层扫描)数据集的主成分分析
J Cereb Blood Flow Metab. 1993 Jan;13(1):5-14. doi: 10.1038/jcbfm.1993.4.
2
Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy.韦尼克脑病中乳头丘脑的功能连接与记忆功能
Brain. 2009 Feb;132(Pt 2):369-76. doi: 10.1093/brain/awn311. Epub 2008 Nov 26.
3
Functional connectivity reveals load dependent neural systems underlying encoding and maintenance in verbal working memory.功能连接揭示了言语工作记忆中编码和维持所依赖的与负荷相关的神经系统。
Neuroscience. 2006 Apr 28;139(1):317-25. doi: 10.1016/j.neuroscience.2005.05.043. Epub 2005 Dec 1.
4
Analyzing the connectivity between regions of interest: an approach based on cluster Granger causality for fMRI data analysis.分析感兴趣区域之间的连通性:基于 fMRI 数据分析的聚类格兰杰因果关系方法。
Neuroimage. 2010 Oct 1;52(4):1444-55. doi: 10.1016/j.neuroimage.2010.05.022. Epub 2010 Jun 1.
5
Functional magnetic resonance image analysis of a large-scale neurocognitive network.大规模神经认知网络的功能磁共振成像分析
Neuroimage. 1996 Aug;4(1):16-33. doi: 10.1006/nimg.1996.0026.
6
Functional connectivity in the brain: effects of anesthesia.大脑的功能连接:麻醉的影响。
Neuroscientist. 2011 Feb;17(1):94-106. doi: 10.1177/1073858410374126.
7
PET activation and language.正电子发射断层扫描激活与语言
Clin Neurosci. 1997;4(2):78-86.
8
Subcortical functional connectivity and verbal episodic memory in healthy elderly--a resting state fMRI study.健康老年人皮质下功能连接与词语情节记忆:一项静息态 fMRI 研究。
Neuroimage. 2010 Aug 1;52(1):379-88. doi: 10.1016/j.neuroimage.2010.03.062. Epub 2010 Mar 27.
9
Functional connectivity between brain regions involved in learning words of a new language.大脑中参与学习新语言单词的区域之间的功能连接。
Brain Lang. 2010 Apr;113(1):21-7. doi: 10.1016/j.bandl.2009.12.005. Epub 2010 Jan 29.
10
Neural network of speech monitoring overlaps with overt speech production and comprehension networks: a sequential spatial and temporal ICA study.语音监测神经网络与公开言语产生及理解神经网络重叠:一项序列时空独立成分分析研究。
Neuroimage. 2009 Oct 1;47(4):1982-91. doi: 10.1016/j.neuroimage.2009.05.057. Epub 2009 May 27.

引用本文的文献

1
Single scan, subject-specific component extraction in dynamic functional connectivity using dictionary learning.使用字典学习在动态功能连接性中进行单次扫描、特定受试者成分提取。
Imaging Neurosci (Camb). 2025 Sep 2;3. doi: 10.1162/IMAG.a.125. eCollection 2025.
2
Multidimensional in silico evaluation of fluorine-18 radiopharmaceuticals: integrating pharmacokinetics, ADMET, and clustering for diagnostic stratification.氟-18放射性药物的多维计算机模拟评估:整合药代动力学、药物代谢及毒性预测和聚类分析用于诊断分层
J Comput Aided Mol Des. 2025 Sep 3;39(1):75. doi: 10.1007/s10822-025-00655-8.
3
Current progress of digital twin construction using medical imaging.
利用医学成像进行数字孪生构建的当前进展。
J Appl Clin Med Phys. 2025 Sep;26(9):e70226. doi: 10.1002/acm2.70226.
4
Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.半球间静息态功能连接与自发神经相互作用相关。
Proc Natl Acad Sci U S A. 2025 Aug 26;122(34):e2505294122. doi: 10.1073/pnas.2505294122. Epub 2025 Aug 18.
5
Molecular connectivity studies in neurotransmission: a scoping review.神经传递中的分子连接性研究:一项范围综述
Imaging Neurosci (Camb). 2025 Apr 4;3. doi: 10.1162/imag_a_00530. eCollection 2025.
6
Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults.对4万人进行的全脑功能连接组分析揭示了在老年人中呈现衰老效应的脑网络。
Imaging Neurosci (Camb). 2024 Dec 16;2. doi: 10.1162/imag_a_00394. eCollection 2024.
7
Unveiling hidden sources of dynamic functional connectome through a novel regularized blind source separation approach.通过一种新型正则化盲源分离方法揭示动态功能连接组的隐藏来源。
Imaging Neurosci (Camb). 2024 Jul 12;2. doi: 10.1162/imag_a_00220. eCollection 2024.
8
Functional connectivity-related changes underlying mindfulness meditation for internet gaming disorder: a randomized clinical trial.基于正念冥想治疗网络成瘾障碍的功能连接相关变化:一项随机临床试验。
Npj Ment Health Res. 2025 Jul 31;4(1):31. doi: 10.1038/s44184-025-00154-6.
9
Structural-functional brain network coupling during cognitive demand reveals intelligence-relevant communication strategies.认知需求期间的结构-功能脑网络耦合揭示了与智力相关的通信策略。
Commun Biol. 2025 Jun 4;8(1):855. doi: 10.1038/s42003-025-08231-4.
10
Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography.连接各个点:探讨正电子发射断层扫描中分子连接性的标准化命名法。
Eur J Nucl Med Mol Imaging. 2025 Jun 2. doi: 10.1007/s00259-025-07357-1.