Chin K V, Pastan I, Gottesman M M
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Adv Cancer Res. 1993;60:157-80. doi: 10.1016/s0065-230x(08)60825-8.
The discovery of an energy-dependent pump system for natural product anticancer drugs has important implications for the biology of related energy-dependent transport systems as well as for the treatment of human cancer. To fully realize the therapeutic potential associated with manipulation of the multidrug transporter, it will be necessary to understand the mechanisms of action of the transporter and its mode of regulation. This review has summarized recent developments in these areas which suggest that both the activity of the pump and its genetic regulation are potential targets for new anticancer therapies.
天然产物抗癌药物能量依赖泵系统的发现，对相关能量依赖转运系统的生物学以及人类癌症治疗都具有重要意义。为了充分实现与多药转运体调控相关的治疗潜力，有必要了解该转运体的作用机制及其调控模式。本综述总结了这些领域的最新进展，表明泵的活性及其基因调控都是新抗癌疗法的潜在靶点。
