Avery D H, Bolte M A, Dager S R, Wilson L G, Weyer M, Cox G B, Dunner D L
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle.
Am J Psychiatry. 1993 Jan;150(1):113-7. doi: 10.1176/ajp.150.1.113.
This study sought to determine whether dawn simulation was superior to a shorter dimmer "placebo" dawn signal in treating winter depression.
In a randomized, parallel design, 22 patients with winter depression were treated with either 1 week of a 2-hour dawn simulation peaking at 250 lux or 1 week of a 30-minute dawn simulation peaking at 0.2 lux. The subjects were told that they would receive either a "gradual" dawn or a "rapid" dawn reaching an intensity that would be dimmer than standard bright light treatment. At the end of both the baseline week and the treatment week, subjects were assessed in a blind manner with the Hamilton Rating Scale for Depression. Analysis of covariance was used to compare the two dawn treatments.
The 2-hour, 250-lux dawn simulation resulted in Hamilton depression scale scores that were significantly lower than scores after the 30-minute, 0.2-lux dawn simulation.
This study indicates that dawn simulation is an effective treatment for winter depression.
本研究旨在确定黎明模拟疗法在治疗冬季抑郁症方面是否优于较短时间的调光“安慰剂”黎明信号。
采用随机平行设计,22例冬季抑郁症患者接受为期1周的黎明模拟治疗,一种是峰值为250勒克斯、持续2小时的黎明模拟,另一种是峰值为0.2勒克斯、持续30分钟的黎明模拟。受试者被告知他们将接受“渐进式”黎明或“快速式”黎明,其达到的强度比标准强光疗法要暗。在基线周和治疗周结束时,采用汉密尔顿抑郁量表对受试者进行盲法评估。采用协方差分析比较两种黎明模拟疗法。
250勒克斯、持续2小时的黎明模拟疗法后的汉密尔顿抑郁量表得分显著低于0.2勒克斯、持续30分钟的黎明模拟疗法后的得分。
本研究表明黎明模拟疗法是治疗冬季抑郁症的有效方法。