Lick S, Copeland J G, Smith R G, Cleavinger M, Rosado L J, Huston C L, Sethi G K, Molloy T F
University of Arizona Health Science Center, Tucson 85715.
Ann Thorac Surg. 1993 Jan;55(1):283-7. doi: 10.1016/0003-4975(93)90538-s.
From 1988 to 1991 13 patients received Symbion biventricular assist devices in attempts to bridge them to cardiac transplantation. All 7 of those who had cardiac transplants survived to hospital discharge. One death occurred 60 days after transplantation because of rejection. All other patients who received transplants are surviving. Implant times in this group varied from 10 to 164 days (mean, 55 days). There were two embolic neurologic events and two significant infections, and 2 of the survivors were dialyzed for reversible renal failure before transplantation. Of those who died on device support, 3 presented on centrifugal pump support. The three other deaths were caused by graft rejection, multiple organ failure, and multiple peripheral emboli. Biventricular assist devices optimally provide cardiac outputs of 4 to 5 L/min, can be quickly inserted often without requiring cardiopulmonary bypass, are easily explanted, and seem best suited for patients weighing less than 80 kg.
1988年至1991年期间，13例患者接受了Symbion双心室辅助装置，试图以此过渡到心脏移植。接受心脏移植的7例患者均存活至出院。1例患者在移植后60天因排斥反应死亡。其他接受移植的患者均存活。该组患者的植入时间为10至164天（平均55天）。发生了2次栓塞性神经系统事件和2次严重感染，2名幸存者在移植前因可逆性肾衰竭接受了透析治疗。在依靠装置支持死亡的患者中，3例使用的是离心泵支持。另外3例死亡原因分别是移植物排斥、多器官功能衰竭和多处外周栓塞。双心室辅助装置最佳可提供4至5升/分钟的心输出量，通常无需体外循环即可快速植入，易于取出，似乎最适合体重低于80公斤的患者。
