Kaplan J, Fredrickson P A, Renaux S A, O'Brien P C
Sleep Disorders Center, Mayo Clinic Jacksonville, Fla 32224.
Chest. 1993 Jan;103(1):193-5. doi: 10.1378/chest.103.1.193.
In an effort to isolate the effect of theophylline on sleep from the effect of asthma, we examined the impact of oral theophylline on sleep quality in normal, nonasthmatic subjects. Ten healthy, nonsmoking, male subjects ranging in age from 23 to 35 were studied. The subjects were randomly divided into two groups and studied in a double-blinded, crossover designed protocol. Each group underwent two consecutive nights in the sleep laboratory. Group one received four doses of 300 mg of sustained-release theophylline at 12-h intervals prior to the study night. Group two received a placebo. After 14 days, the patients crossed over to the other group, and the procotcol was repeated. The mean serum theophylline level on the morning following the study night was 7.85 +/- SD 2.12 micrograms/ml, with a range of 5.1 to 12.1 microns/ml. The analysis of variance for a crossover design showed no order effect. The analysis for drug effect showed that theophylline administration resulted in a statistically significant adverse effect on arousals per sleep hour (19.3 vs 15.9 for placebo, p = .006) and total sleep time (370.9 min vs 399.45 min for placebo, p = .015). Comparing the sum of ranks data, theophylline was found to have a significant adverse effect on sleep quality (p = .036). We conclude that low doses of oral theophylline result in a significant disturbance in sleep quality in normal nonasthmatic subjects.
为了将茶碱对睡眠的影响与哮喘的影响隔离开来，我们研究了口服茶碱对正常非哮喘受试者睡眠质量的影响。研究了10名年龄在23至35岁之间的健康、不吸烟男性受试者。受试者被随机分为两组，并按照双盲、交叉设计方案进行研究。每组在睡眠实验室连续度过两个晚上。第一组在研究当晚前每隔12小时服用四剂300毫克缓释茶碱。第二组服用安慰剂。14天后，患者交叉到另一组，并重复该方案。研究当晚后的早晨，血清茶碱平均水平为7.85±标准差2.12微克/毫升，范围为5.1至12.1微克/毫升。交叉设计的方差分析显示无顺序效应。药物效应分析表明，服用茶碱对每睡眠小时的觉醒次数（安慰剂组为15.9次，茶碱组为19.3次，p = 0.006）和总睡眠时间（安慰剂组为399.45分钟，茶碱组为370.9分钟，p = 0.015）产生了统计学上显著的不良影响。比较秩和数据，发现茶碱对睡眠质量有显著的不良影响（p = 0.036）。我们得出结论，低剂量口服茶碱会导致正常非哮喘受试者的睡眠质量出现显著紊乱。
