一项关于人类对恶性疟原虫血液期抗原gp190的体液免疫反应与疟疾感染控制之间关联的前瞻性研究。
A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections.
作者信息
Tolle R, Früh K, Doumbo O, Koita O, N'Diaye M, Fischer A, Dietz K, Bujard H
机构信息
Zentrum für Molekulare Biologie, INF 282, Heidelberg, Germany.
出版信息
Infect Immun. 1993 Jan;61(1):40-7. doi: 10.1128/iai.61.1.40-47.1993.
Abstract
The human humoral immune response to the Plasmodium falciparum merozoite surface antigen gp190 was analyzed to determine the rate of reinfection by the parasite and the ability to control parasite density. The prospective study was carried out in a West African village where malaria is hyperendemic. No correlation between the antibody titers and protection against infection was observed within the group of children. Positive and negative associations of antibody specificities with protection against and/or control of parasitemia were, however, found for adolescents and adults, respectively. Thus, in adolescents, the presence of antibodies to gp190 fragment M6 correlates with a 50% reduced risk of P. falciparum infection and an increased ability to control parasitemia, whereas in adults, the humoral response to some of the polymorphic regions of gp190 associates with an increased risk of infection.
摘要
对人类针对恶性疟原虫裂殖子表面抗原gp190的体液免疫反应进行了分析，以确定寄生虫的再感染率和控制寄生虫密度的能力。这项前瞻性研究在西非一个疟疾高度流行的村庄开展。在儿童组中未观察到抗体滴度与预防感染之间的相关性。然而，分别在青少年和成年人中发现了抗体特异性与预防和/或控制寄生虫血症之间的正相关和负相关。因此，在青少年中，针对gp190片段M6的抗体的存在与恶性疟原虫感染风险降低50%以及控制寄生虫血症的能力增强相关，而在成年人中，对gp190某些多态性区域的体液反应与感染风险增加相关。
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