用于评估梗阻性尿路病肾功能的胎儿尿液分析
Fetal urine analysis for the assessment of renal function in obstructive uropathy.
作者信息
Lipitz S, Ryan G, Samuell C, Haeusler M C, Robson S C, Dhillon H K, Nicolini U, Rodeck C H
机构信息
Fetal Medicine Unit, University College Hospital, London, England.
出版信息
Am J Obstet Gynecol. 1993 Jan;168(1 Pt 1):174-9. doi: 10.1016/s0002-9378(12)90909-6.
OBJECTIVES
The assessment of fetal renal function plays a key role in the evaluation of posterior urethral valve obstruction cases. The aim of our study was to determine the value of several urinary compounds, including beta 2-microglobulin, N-acetyl-beta-D-glucosaminidase, and microalbumin in the assessment of prenatal renal function in cases of posterior urethral valve and their potential role in the selection of such cases for in utero shunting.
STUDY DESIGN
A range of urinary compounds was measured, including beta 2-microglobulin, N-acetyl-beta-D-glucosaminidase, and microalbumin in 25 cases of posterior urethral valve obstruction. These cases were divided into four groups based on outcome. The Mann-Whitney test and analysis of covariance were used.
RESULTS
Sodium, calcium, and beta 2-microglobulin were the best predictors for fetal survival. beta 2-Microglobulin values > 13 mg/L were almost invariably associated with fatal outcome.
CONCLUSION
The estimation of beta 2-microglobulin may help in counseling parents and in selecting cases for in utero shunting.
目的
胎儿肾功能评估在后尿道瓣膜梗阻病例的评估中起着关键作用。我们研究的目的是确定几种尿化合物，包括β2-微球蛋白、N-乙酰-β-D-氨基葡萄糖苷酶和微量白蛋白，在评估后尿道瓣膜病例产前肾功能中的价值，以及它们在选择此类病例进行宫内分流中的潜在作用。
研究设计
测量了25例后尿道瓣膜梗阻病例中的一系列尿化合物，包括β2-微球蛋白、N-乙酰-β-D-氨基葡萄糖苷酶和微量白蛋白。根据结果将这些病例分为四组。采用曼-惠特尼检验和协方差分析。
结果
钠、钙和β2-微球蛋白是胎儿存活的最佳预测指标。β2-微球蛋白值>13mg/L几乎总是与致命结局相关。
结论
β2-微球蛋白的测定可能有助于为父母提供咨询，并选择病例进行宫内分流。
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