糖尿病性黄斑水肿激光治疗后的视网膜血管收缩

Retinal vasoconstriction after laser treatment for diabetic macular edema.

作者信息

Gottfredsdóttir M S, Stefánsson E, Jónasson F, Gíslason I

机构信息

Department of Ophthalmology, University of Iceland, Landakotsspítali, Reykjavík.

出版信息

Am J Ophthalmol. 1993 Jan;115(1):64-7. doi: 10.1016/s0002-9394(14)73526-3.

DOI:10.1016/s0002-9394(14)73526-3

PMID:8420380

Abstract

The diameter of retinal arterioles, venules, and their macular branches was measured before and after macular laser photocoagulation in one eye each of six men and eight women with diabetic macular edema. The macular arteriolar branches constricted 20.2% (P < .001) and the venular branches constricted 13.8% (P < .001). This autoregulatory vasoconstriction results from the improved retinal oxygenation caused by the laser treatment. By extrapolating the principles of tissue edema formation in general, we hypothesized how macular laser treatment affects diabetic macular edema. Starling's law predicts that (laser-induced) vasoconstriction and reduced intravascular hydrostatic pressure should reduce edema formation in any tissue, including the retina.

摘要

在6名男性和8名患有糖尿病性黄斑水肿的女性中，分别对其一只眼睛进行黄斑激光光凝治疗，测量治疗前后视网膜小动脉、小静脉及其黄斑分支的直径。黄斑小动脉分支收缩了20.2%（P < .001），小静脉分支收缩了13.8%（P < .001）。这种自动调节性血管收缩是由激光治疗引起的视网膜氧合改善所致。通过外推一般组织水肿形成的原理，我们推测了黄斑激光治疗对糖尿病性黄斑水肿的影响。根据斯塔林定律预测，（激光诱导的）血管收缩和血管内静水压力降低应会减少包括视网膜在内的任何组织中的水肿形成。