Vaziri N D, Eltorai I M, Segal J, Winer R L, Gonzales E, Brunnemann S, Elmzadeh M
Division of Nephrology, University of California, Irvine.
Arch Phys Med Rehabil. 1993 Jan;74(1):65-7.
Patients with spinal cord injury (SCI) have a high incidence of anemia. Intact erythropoietin (EPO) production is essential to the maintenance of erythrocyte mass and prevention and correction of anemia. However, the effect of chronic SCI on EPO production remains unclear. We measured plasma EPO concentration in 83 men with longstanding SCI and a group of normal able-bodied individuals. The SCI patients showed a significant reduction in hematocrit, a high prevalence of anemia, and an increased plasma EPO concentration. Active smokers showed a significantly higher hematocrit and lower EPO concentration than nonsmokers. No significant difference was found in hematocrit or EPO between individuals with paraplegia and those with quadriplegia. A negative correlation was found between EPO and hematocrit in SCI patients lacking significant lung disease. Thus, in the absence of renal insufficiency, EPO response to anemia is qualitatively preserved in SCI patients and is largely independent of the level of injury.
脊髓损伤（SCI）患者贫血发生率较高。完整的促红细胞生成素（EPO）生成对于维持红细胞数量以及预防和纠正贫血至关重要。然而，慢性脊髓损伤对EPO生成的影响仍不清楚。我们测量了83名患有长期脊髓损伤的男性以及一组正常健康个体的血浆EPO浓度。脊髓损伤患者的血细胞比容显著降低，贫血患病率较高，血浆EPO浓度升高。与不吸烟者相比，主动吸烟者的血细胞比容显著更高，EPO浓度更低。截瘫患者和四肢瘫患者之间的血细胞比容或EPO未发现显著差异。在没有严重肺部疾病的脊髓损伤患者中，EPO与血细胞比容呈负相关。因此，在没有肾功能不全的情况下，脊髓损伤患者对贫血的EPO反应在质量上得以保留，并且在很大程度上与损伤水平无关。
