Keck K, Bergmann B
Z Immunitatsforsch Immunobiol. 1977 Feb;152(5):415-22.
The immune response of mice to guinea pig insulin (as well as to insulins from other species) is controlled by immune response genes. The immunogenicity of guinea pig insulin is generally much lower than that of bovine insulin, through there are 14 sequence differences between mouse insulin and guinea pig insulin as compared to 5 sequence differences between mouse insulin and bovine insulin, respectively. The low immunogenicity of guinea pig insulin is indicated by a low frequency of responder strains and the requirement for high antigen doses for immunisation. Guinea pig and bovine insulin do not cross-react at the antibody level, but there seems to be some cross-recognition at the carrier level, as indicated by the capability of guinea pig insulin primed spleen cells to provide help for the pig insulin carrier in cooperative cell transfer.
小鼠对豚鼠胰岛素（以及其他物种的胰岛素）的免疫反应受免疫反应基因控制。豚鼠胰岛素的免疫原性通常远低于牛胰岛素，尽管小鼠胰岛素与豚鼠胰岛素之间有14个序列差异，而小鼠胰岛素与牛胰岛素之间分别有5个序列差异。豚鼠胰岛素的低免疫原性表现为反应品系频率低以及免疫时需要高剂量抗原。豚鼠胰岛素和牛胰岛素在抗体水平上不发生交叉反应，但在载体水平上似乎存在一些交叉识别，这表现为用豚鼠胰岛素致敏的脾细胞在协同细胞转移中能够为猪胰岛素载体提供辅助。
