Black D W, Wesner R, Bowers W, Gabel J
Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
Arch Gen Psychiatry. 1993 Jan;50(1):44-50. doi: 10.1001/archpsyc.1993.01820130046008.
Seventy-five outpatients with moderate to severe panic disorder were randomly assigned to receive 8 weeks of fluvoxamine, cognitive therapy, or placebo. Fifty-five patients completed the treatment protocol. Fluvoxamine was found to be an effective and well-tolerated treatment for panic using clinician- and patient-rated variables. Subjects receiving cognitive therapy also showed improvement, but this improvement did not significantly differ from the experience of the placebo-treated group for most comparisons. Fluvoxamine was superior to cognitive therapy for many ratings, but cognitive therapy was not superior to fluvoxamine on any rating. Fluvoxamine also produced improvement earlier than cognitive therapy. At the main comparison point (week 4), 57% (13/23) of patients receiving fluvoxamine were rated moderately improved or better vs 40% (8/20) of the group given cognitive therapy and 22% (5/23) of the placebo-treated group. At that point, 43% (10/23) of the fluvoxamine recipients vs 25% (5/20) of cognitive therapy and 4% (1/23) of placebo recipients were free of panic attacks.
75名中重度惊恐障碍门诊患者被随机分配接受8周的氟伏沙明治疗、认知疗法或安慰剂治疗。55名患者完成了治疗方案。使用临床医生和患者评定的变量发现，氟伏沙明是一种治疗惊恐有效的且耐受性良好的治疗方法。接受认知疗法的受试者也有改善，但在大多数比较中，这种改善与安慰剂治疗组的情况没有显著差异。在许多评定中，氟伏沙明优于认知疗法，但在任何评定中认知疗法都不优于氟伏沙明。氟伏沙明也比认知疗法更早产生改善效果。在主要比较点（第4周），接受氟伏沙明治疗的患者中有57%（13/23）被评定为中度改善或更好，而接受认知疗法的组为40%（8/20），安慰剂治疗组为22%（5/23）。此时，接受氟伏沙明治疗的患者中有43%（10/23）无惊恐发作，接受认知疗法的为25%（5/20），接受安慰剂治疗的为4%（1/23）。
