Launoy G, Gignoux M, Pottier D, Lefort F, Soumrany A, Maurel J, Beck A
Registre spécialisé des tumeurs digestives du Calvados, Faculté de Médecine CHRU, Côte de Nacre, Caen, France.
Eur J Cancer. 1993;29A(2):263-6. doi: 10.1016/0959-8049(93)90189-m.
We studied changes in the prognosis of cancer of the rectum (excluding the rectosigmoid junction) from 1978 to 1986 in the French department of Calvados on the basis of the 616 cases in the cancer registry. Taken as whole, survival has improved slightly with time (P < 0.01), but the improvement is only significant for men (P < 0.02), patients under 70 years (P < 0.01) and patients living in urban areas (P < 0.05). With regard to tumour characteristics, the improvement was significant only for patients with Dukes' stage C tumours at surgery (P < 0.02). To determine the reasons for the improvement in survival, the year of diagnosis and all other prognostic factors were studied in a multivariate model. Diagnostic conditions such as age and tumour stage did not vary from 1978 to 1986; in contrast, the rates of tumour resection and adjuvant radiation therapy increased, possibly explaining at least part of the improvement, particularly for patients with Dukes' stage C tumours.
我们基于卡尔瓦多斯省癌症登记处的616例病例，研究了1978年至1986年法国卡尔瓦多斯省直肠癌（不包括直肠乙状结肠交界处）预后的变化。总体而言，生存率随时间略有提高（P < 0.01），但这种改善仅在男性（P < 0.02）、70岁以下患者（P < 0.01）和城市地区患者（P < 0.05）中显著。关于肿瘤特征，仅手术时为Dukes C期肿瘤的患者生存率改善显著（P < 0.02）。为了确定生存率提高的原因，我们在多变量模型中研究了诊断年份和所有其他预后因素。1978年至1986年期间，年龄和肿瘤分期等诊断条件没有变化；相反，肿瘤切除率和辅助放疗率有所提高，这可能至少部分解释了生存率的提高，特别是对于Dukes C期肿瘤的患者。
