Van Hilten J J, Hoogland G, van der Velde E A, van Dijk J G, Kerkhof G A, Roos R A
Department of Neurology and Clinical Neurophysiology, Academic Hospital, Leiden, The Netherlands.
Clin Neuropharmacol. 1993 Feb;16(1):36-45. doi: 10.1097/00002826-199302000-00004.
The aim of this study was to examine the quantitative relationship between activity monitor measures and clinical scores of patients with Parkinson disease (PD). Motor activity was recorded continuously for 5 to 6 days at home with a wrist-worn activity monitor in 69 PD patients and 59 healthy controls. Clinical scores of the patients, age, and sex were submitted to multiple regression analysis to examine the quantitative relationship with measures reflecting the activity level and the proportion of activity and immobility over time. The patients' age, sex, and scores representing hypokinesia and rigidity and resting tremor explained approximately 50% of the variance of the motor activity measures. All motor activity measures declined with age; the rate of decline was similar for the patients and controls. Sex emerged as a predictor of the motor activity measures in the patients only. Male patients with PD showed significantly lower values for all motor activity measures than female patients and controls. Our results show that activity monitoring can be used as an objective quantitative assessment in PD.
本研究的目的是探讨帕金森病（PD）患者活动监测指标与临床评分之间的定量关系。使用腕部佩戴的活动监测器，对69例PD患者和59名健康对照者进行了为期5至6天的家庭连续运动活动记录。将患者的临床评分、年龄和性别进行多元回归分析，以检验与反映活动水平以及活动和静止时间比例的指标之间的定量关系。患者的年龄、性别以及代表运动迟缓、僵硬和静止性震颤的评分解释了运动活动指标约50%的方差。所有运动活动指标均随年龄下降；患者和对照者的下降速率相似。仅在患者中，性别成为运动活动指标的一个预测因素。男性PD患者的所有运动活动指标值均显著低于女性患者和对照者。我们的结果表明，活动监测可作为PD的一种客观定量评估方法。
