父母年龄、基因突变与脑瘫。
Parental age, genetic mutation, and cerebral palsy.
作者信息
Fletcher N A, Foley J
机构信息
Department of Neurological Sciences, St Bartholomew's Hospital, London.
出版信息
J Med Genet. 1993 Jan;30(1):44-6. doi: 10.1136/jmg.30.1.44.
Abstract
Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.
摘要
对251例脑瘫患者的父母年龄和出生顺序进行了研究。在痉挛性四肢瘫或双瘫患者中未观察到父母年龄或出生顺序的影响，但在手足徐动型/张力障碍型脑瘫和先天性偏瘫患者中发现了父亲年龄的影响。这些观察结果表明，一些手足徐动型/张力障碍型或偏瘫型脑瘫病例可能是由新的显性基因突变引起的。
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