• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Parental age, genetic mutation, and cerebral palsy.父母年龄、基因突变与脑瘫。
J Med Genet. 1993 Jan;30(1):44-6. doi: 10.1136/jmg.30.1.44.
2
[Magnetic resonance imaging findings in children with cerebral palsy].[脑瘫患儿的磁共振成像表现]
Zhonghua Er Ke Za Zhi. 2004 Feb;42(2):125-8.
3
MRI findings in patients with spastic cerebral palsy. II: Correlation with type of cerebral palsy.痉挛型脑瘫患者的MRI表现。II：与脑瘫类型的相关性。
Dev Med Child Neurol. 1997 Jun;39(6):369-72.
4
Genetic factors in athetoid cerebral palsy.手足徐动型脑性瘫痪的遗传因素
J Child Neurol. 2001 Nov;16(11):793-7. doi: 10.1177/08830738010160110301.
5
[MR imaging of cerebral palsy].[脑性瘫痪的磁共振成像]
Nihon Igaku Hoshasen Gakkai Zasshi. 1996 Jun;56(7):490-5.
6
[A clinical study of cerebral palsy in Shiga; 1977-1986--III. Diagnosis and treatment of various types of cerebral palsy].滋贺县脑性瘫痪的临床研究；1977 - 1986年——III. 各类脑性瘫痪的诊断与治疗
No To Hattatsu. 1999 Jul;31(4):343-7.
7
Cerebral palsy: predictive value of selected clinical signs for early prognostication of motor function.脑瘫：特定临床体征对运动功能早期预后的预测价值
Arch Phys Med Rehabil. 1976 Apr;57(4):153-8.
8
Early diagnosis of spastic diplegia, spastic hemiplegia, and quadriplegia.痉挛性双侧瘫、痉挛性偏瘫和四肢瘫的早期诊断。
Am J Dis Child. 1989 Nov;143(11):1356-60. doi: 10.1001/archpedi.1989.02150230114038.
9
Occlusal characteristics in cerebral palsy patients.脑瘫患者的咬合特征。
J Dent Child (Chic). 2007 Jan-Apr;74(1):41-5.
10
Sensory disorders in cerebral palsy: two-point discrimination.
Dev Med Child Neurol. 1993 May;35(5):402-5. doi: 10.1111/j.1469-8749.1993.tb11661.x.

引用本文的文献

1
Determinants of cerebral palsy in children: systematic review.儿童脑瘫的决定因素：系统评价
Sudan J Paediatr. 2023;23(2):126-144. doi: 10.24911/SJP.106-1670589241.
2
Parental Age and Childhood Risk for Cerebral Palsy in California.加利福尼亚的父母年龄与儿童脑瘫风险。
J Pediatr. 2023 Apr;255:147-153.e6. doi: 10.1016/j.jpeds.2022.10.039. Epub 2022 Nov 11.
3
In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy.深入分析揭示了特发性脑瘫患者队列中的复杂分子病因。
Brain. 2022 Mar 29;145(1):119-141. doi: 10.1093/brain/awab209.
4
A new family with spastic paraplegia type 51 and novel mutations in AP4E1.一个新的痉挛性截瘫 51 型家系和 AP4E1 中的新突变。
BMC Med Genomics. 2021 May 18;14(1):131. doi: 10.1186/s12920-021-00980-5.
5
Insights From Genetic Studies of Cerebral Palsy.脑瘫遗传学研究的见解
Front Neurol. 2021 Jan 21;11:625428. doi: 10.3389/fneur.2020.625428. eCollection 2020.
6
The Effect of Paternal Age on Relapse in First-Episode Schizophrenia.父亲年龄对首发精神分裂症复发的影响。
Can J Psychiatry. 2015 Aug;60(8):346-53. doi: 10.1177/070674371506000803.
7
De novo point mutations in patients diagnosed with ataxic cerebral palsy.在诊断为共济失调性脑瘫的患者中发现的新的点突变。
Brain. 2015 Jul;138(Pt 7):1817-32. doi: 10.1093/brain/awv117. Epub 2015 May 16.
8
Disproportionate fetal growth and the risk for congenital cerebral palsy in singleton births.单胎分娩中胎儿生长不均衡与先天性脑瘫风险
PLoS One. 2015 May 14;10(5):e0126743. doi: 10.1371/journal.pone.0126743. eCollection 2015.
9
Intra-partum fever and cerebral palsy in Khartoum, Sudan.苏丹喀土穆的产时发热与脑瘫
BMC Res Notes. 2013 Apr 24;6:163. doi: 10.1186/1756-0500-6-163.
10
Genetic [corrected] insights into the causes and classification of [corrected] cerebral palsies.遗传[修正]见解对脑性瘫痪的病因和分类[修正]。
Lancet Neurol. 2012 Mar;11(3):283-92. doi: 10.1016/S1474-4422(11)70287-3. Epub 2012 Jan 18.

本文引用的文献

1
A survey of 400 cases of cerebral palsy in childhood.一项针对400例儿童脑瘫病例的调查。
Arch Dis Child. 1950 Dec;25(124):360-79. doi: 10.1136/adc.25.124.360.
2
Familial cerebral palsy.家族性脑瘫
J Chronic Dis. 1961 Mar;13:207-14. doi: 10.1016/0021-9681(61)90077-7.
3
Parental age and mutation.父母年龄与突变
Lancet. 1955 Aug 13;269(6885):312-3. doi: 10.1016/s0140-6736(55)92305-9.
4
Dyskinetic cerebral palsy. I. Clinical categories, associated neurological abnormalities and incidences.
Acta Paediatr Scand. 1982 Jul;71(4):543-50. doi: 10.1111/j.1651-2227.1982.tb09472.x.
5
Dyskinetic cerebral palsy. II. Pathogenetic risk factors and intra-uterine growth.
Acta Paediatr Scand. 1982 Jul;71(4):551-8. doi: 10.1111/j.1651-2227.1982.tb09473.x.
6
The athetoid syndrome. A review of a personal series.手足徐动症综合征。个人病例系列回顾。
J Neurol Neurosurg Psychiatry. 1983 Apr;46(4):289-98. doi: 10.1136/jnnp.46.4.289.
7
Sex-linked spastic paraplegia.性连锁痉挛性截瘫
Am J Ment Defic. 1966 Jul;71(1):13-8.
8
Note on the estimation of parental age effects.
Ann Hum Genet. 1972 Mar;35(3):337-42. doi: 10.1111/j.1469-1809.1957.tb01407.x.
9
Genetic syndromes associated with cerebral palsy.与脑瘫相关的遗传综合征。
Clin Orthop Relat Res. 1974 Mar-Apr(99):2-11. doi: 10.1097/00003086-197403000-00001.
10
Antecedents of cerebral palsy. Multivariate analysis of risk.脑瘫的前驱因素。风险的多变量分析。
N Engl J Med. 1986 Jul 10;315(2):81-6. doi: 10.1056/NEJM198607103150202.

父母年龄、基因突变与脑瘫。

Parental age, genetic mutation, and cerebral palsy.

作者信息

Fletcher N A, Foley J

机构信息

Department of Neurological Sciences, St Bartholomew's Hospital, London.

出版信息

J Med Genet. 1993 Jan;30(1):44-6. doi: 10.1136/jmg.30.1.44.

DOI:10.1136/jmg.30.1.44
PMID:8423607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1016233/
Abstract

Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.

摘要

对251例脑瘫患者的父母年龄和出生顺序进行了研究。在痉挛性四肢瘫或双瘫患者中未观察到父母年龄或出生顺序的影响，但在手足徐动型/张力障碍型脑瘫和先天性偏瘫患者中发现了父亲年龄的影响。这些观察结果表明，一些手足徐动型/张力障碍型或偏瘫型脑瘫病例可能是由新的显性基因突变引起的。