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一项关于血管加压素类似物(去氨加压素)对头外伤后即刻认知恢复影响的对照试验。

A controlled trial with vasopressin analogue (DGAVP) on cognitive recovery immediately after head trauma.

作者信息

Bohnen N I, Twijnstra A, Jolles J

机构信息

Department of Neuropsychology and Psychobiology, University of Limburg, Maastricht, The Netherlands.

出版信息

Neurology. 1993 Jan;43(1):103-6. doi: 10.1212/wnl.43.1_part_1.103.

DOI:10.1212/wnl.43.1_part_1.103
PMID:8423870
Abstract

Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, matched-pairs study. DGAVP did not have a positive effect on cognitive recovery in this group of mildly affected patients.

摘要

最近的证据表明,血管加压素类似物去甘氨酰胺-精氨酸8-血管加压素(DGAVP)可能对轻度脑外伤患者有特别的益处。在一项双盲、安慰剂对照、配对研究中,我们调查了鼻内给予DGAVP治疗对32例轻度头部受伤3个月患者的影响。在这组轻度受影响的患者中,DGAVP对认知恢复没有积极作用。

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