de Kruijk J R, Leffers P, Meerhoff S, Rutten J, Twijnstra A
Department of Neurology, University Hospital Maastricht, The Netherlands.
J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):167-72. doi: 10.1136/jnnp.73.2.167.
Outcome after mild traumatic brain injury (MTBI) is determined largely by the appearance of post-traumatic complaints (PTC). The prevalence of PTC after six months is estimated to be between 20 and 80%. Bed rest has been advocated to prevent PTC but its effectiveness has never been established.
To evaluate the effect of bed rest on the severity of PTC after MTBI.
Patients presenting with MTBI to the emergency room were randomly assigned to two intervention strategies. One group was advised not to take bed rest (NO) and the other to take full bed rest (FULL) for six days after the trauma. The primary outcome measures were severity of PTC on a visual analogue scale and physical and mental health on the medical outcomes study 36 item short form health survey (SF-36) at two weeks and three and six months after the trauma.
Between October 1996 and July 1999, 107 (54 NO, 53 FULL) patients were enrolled. Outcome variables in both groups clearly improved between two weeks and six months. After adjustment for differences in baseline variables, most PTC tended to be somewhat more severe in the FULL group six months after the trauma, but no significant differences were found. Neither were there any significant differences in the outcome parameters between the two groups after three months. Two weeks after the trauma, most PTC in the FULL group were slightly less severe than those in the NO group, and physical subscores of the SF-36 in the FULL group were slightly better. These differences were not significant. Patients in the FULL group reported significantly less dizziness during the intervention period.
As a means of speeding up recovery of patients with PTC after MTBI, bed rest is no more effective than no bed rest at all. Bed rest probably has some palliative effect within the first two weeks after the trauma.
轻度创伤性脑损伤(MTBI)后的预后很大程度上取决于创伤后症状(PTC)的出现情况。据估计,六个月后PTC的患病率在20%至80%之间。有人主张卧床休息以预防PTC,但其有效性从未得到证实。
评估卧床休息对MTBI后PTC严重程度的影响。
到急诊室就诊的MTBI患者被随机分配到两种干预策略组。一组被建议不卧床休息(NO组),另一组在受伤后完全卧床休息六天(FULL组)。主要结局指标为创伤后两周、三个月和六个月时,采用视觉模拟量表评估PTC的严重程度,以及采用医学结局研究36项简短健康调查(SF - 36)评估身心健康状况。
在1996年10月至1999年7月期间,共纳入107例患者(54例NO组,53例FULL组)。两组的结局变量在两周至六个月之间均有明显改善。在对基线变量差异进行调整后,创伤后六个月时,FULL组的大多数PTC往往略比NO组严重,但未发现显著差异。三个月后两组的结局参数也没有显著差异。创伤后两周时,FULL组的大多数PTC比NO组略轻,且FULL组SF - 36的身体分项评分略好。这些差异不显著。FULL组患者在干预期间报告头晕的情况明显较少。
作为加速MTBI后PTC患者康复的一种方法,卧床休息并不比完全不卧床休息更有效。卧床休息可能在创伤后的前两周内有一定的缓解作用。