Natelson B H, Tapp W N, Drastal S, Gross J, Ottenweller J E
Neurobehavioral Unit, Veterans Affairs Medical Center, East Orange, New Jersey 07019.
Proc Soc Exp Biol Med. 1993 Jan;202(1):69-74. doi: 10.3181/00379727-202-43513.
Our previous work has shown that constant light can prolong the life of hamsters with heart disease. Although we have seen this result several times, constant light was not protective in our most recent experiment. We undertook this study because we had changed some conditions. As in previous experiments, we found that life in constant light extended life for cardiomyopathic hamsters as compared with others living in a 12:12-hr light:dark environment. A second factor affecting survival was the number of hamsters in a group. Hamsters housed in groups of five lived longer than those housed in groups of two under the same lighting conditions. Data from one experiment suggested that a short photoperiod (6:18 light:dark) was also protective. Although these experiments indicate that the protective effects of different light:dark schedules are not simple ones, they are important because their use may prove to be a helpful adjunct in the treatment of congestive heart failure.
我们之前的研究表明，持续光照可以延长患心脏病仓鼠的寿命。尽管我们多次看到这一结果，但在我们最近的实验中，持续光照并没有起到保护作用。我们进行这项研究是因为我们改变了一些条件。与之前的实验一样，我们发现，与生活在12小时光照：12小时黑暗环境中的仓鼠相比，持续光照环境下的心肌病变仓鼠寿命更长。影响存活的第二个因素是每组仓鼠的数量。在相同光照条件下，五只一组饲养的仓鼠比两只一组饲养的仓鼠寿命更长。一项实验的数据表明，短光照周期（6小时光照：18小时黑暗）也具有保护作用。尽管这些实验表明，不同光照：黑暗时间表的保护作用并非简单直接，但它们很重要，因为其应用可能被证明是治疗充血性心力衰竭的有益辅助手段。
