Baldeweg T, Gruzelier J H, Catalan J, Pugh K, Lovett E, Riccio M, Stygall J, Irving G, Catt S, Hawkins D
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, London, UK.
Electroencephalogr Clin Neurophysiol. 1993 Sep-Oct;88(5):356-68. doi: 10.1016/0168-5597(93)90012-e.
Auditory and visual event-related brain potentials (ERPs) were used to complement neuropsychological and medical assessment in neurologically healthy subjects with asymptomatic and symptomatic human immunodeficiency virus type 1 (HIV-1) infection. Auditory and visual ERPs, recorded using standard oddball paradigms, disclosed delays in late waves (N2 and P3) in symptomatic subjects (CDC stage IV) when compared with matched controls. Abnormally delayed P3 waves in at least one modality were recorded in 41% of symptomatics and this was associated with deficits in neuropsychological performance, particularly psychomotor slowing. However, no differences in late wave latencies between asymptomatic and control subjects were found, though asymptomatics showed delays in auditory N1 and P2 latencies. The number of morphological abnormalities, such as indiscernible late waves as well as topographical variability of the P3 wave, was increased in both HIV seropositive groups and possibly indicates a distinct mechanism of impairment, different from latency delay. Whilst P3 delay in symptomatics was not associated with changes in immune function (T4 cells) there was, however, a link with anaemia and subclinical hepatic dysfunction.
听觉和视觉事件相关脑电位（ERP）被用于补充对无症状和有症状的1型人类免疫缺陷病毒（HIV-1）感染的神经功能正常受试者的神经心理学和医学评估。使用标准的oddball范式记录的听觉和视觉ERP显示，与匹配的对照组相比，有症状的受试者（疾病控制中心IV期）的晚波（N2和P3）出现延迟。41%的有症状受试者至少在一种模式下记录到P3波异常延迟，这与神经心理学表现缺陷有关，尤其是精神运动迟缓。然而，无症状受试者和对照组之间在晚波潜伏期方面未发现差异，尽管无症状受试者的听觉N1和P2潜伏期出现延迟。HIV血清阳性组的形态学异常数量增加，如无法分辨的晚波及P3波的地形变异，这可能表明存在一种不同于潜伏期延迟的独特损伤机制。虽然有症状受试者的P3延迟与免疫功能（T4细胞）变化无关，但与贫血和亚临床肝功能障碍有关。
