Bonifati V, Vanacore N, Bellatreccia A, Meco G
Department of Neurological Sciences, La Sapienza University, Rome, Italy.
Acta Neurol Scand. 1993 Jan;87(1):9-13. doi: 10.1111/j.1600-0404.1993.tb04067.x.
Parkinsonism death rates in Italy were analysed for the period 1969-1987. Crude death rates increased markedly in the above period for both sexes. Age-specific rates underwent important changes during these twenty years. In the years 1969-71 the age-specific death rates reach their maximum values at ages 80-84, after which they decline. In the years 1983-87 the rates continue to increase until the 80-84 age group, when they reach a plateau. Moreover, in the more recent years the age-specific rates for ages < 70-75 are lower, whereas those for the older ages are approximately twice as high as the values in the earlier years. The age-adjusted death rates (1981 Italian population) increased slightly in the period studied for both sexes. Rates for males exceed those for females in all the previous analyses. Minor differences appeared in death distribution between the five large areas Italy was divided into. The observed changes in death rates are likely to reflect: changes in age composition of the population over time, greater attention to parkinsonian patients and especially increased duration of this disease following the discovery of its neurochemical basis and effective medical treatment.
对1969年至1987年期间意大利帕金森症死亡率进行了分析。在此期间，两性的粗死亡率均显著上升。年龄别死亡率在这二十年中发生了重要变化。在1969 - 1971年期间，年龄别死亡率在80 - 84岁达到最大值，此后开始下降。在1983 - 1987年期间，该比率持续上升，直至80 - 84岁年龄组，之后趋于平稳。此外，近年来，70 - 75岁以下年龄组的年龄别死亡率较低，而老年组的死亡率约为早期的两倍。按年龄调整后的死亡率（以1981年意大利人口为标准）在研究期间两性均略有上升。在之前的所有分析中，男性的死亡率均高于女性。意大利划分的五个大区在死亡分布上存在细微差异。观察到的死亡率变化可能反映了：随着时间推移人口年龄构成的变化、对帕金森症患者的更多关注，尤其是在发现该病的神经化学基础并采取有效治疗后病程的延长。
