Sandel M E, Olive D A, Rader M A
Magee Rehabilitation Hospital, Philadelphia, PA 19102.
Brain Inj. 1993 Jan-Feb;7(1):77-83. doi: 10.3109/02699059309008159.
Antipsychotic agents, most often used for treatment of schizophrenia, are sometimes prescribed for the agitated patient with an organic brain disorder. We report the case of a brain-injured patient who was prescribed chlorpromazine for agitation and who developed a delusional state while taking this antipsychotic agent. The emergence of this delusional state coincided with the exacerbation of certain cognitive deficits. Possible mechanisms for this phenomenon are discussed. Caution is advised when prescribing neuroleptics for patients with traumatic brain injury, especially those agents with significant cognitive side-effects or with a significant potential to precipitate seizures.
抗精神病药物最常用于治疗精神分裂症，有时也会给患有器质性脑障碍的躁动患者开此类药物。我们报告了一例脑损伤患者的病例，该患者因躁动被开了氯丙嗪，在服用这种抗精神病药物期间出现了妄想状态。这种妄想状态的出现与某些认知缺陷的加重同时发生。本文讨论了这一现象可能的机制。建议在给创伤性脑损伤患者开神经安定药时要谨慎，尤其是那些具有明显认知副作用或有显著癫痫发作风险的药物。
