Lambert S, Bennett V
Howard Hughes Medical Institute, Duke University Medical Center, Durham 27710.
Eur J Biochem. 1993 Jan 15;211(1-2):1-6. doi: 10.1111/j.1432-1033.1993.tb19863.x.
The focus of this review is on the ankyrin gene family, key elements in the interaction of the spectrin-based membrane skeleton with the plasma membrane in a variety of tissues and multicellular organisms. The structure/function relationships of ankyrin molecules are reviewed, illustrating how these proteins are uniquely suited to serve as adaptors between the membrane skeleton and a number of integral membrane proteins. Advances in the understanding of ankyrin biology in the brain are discussed and used to show how ankyrins may be involved in the establishment and/or maintenance of specialized plasma membrane domains. Finally, recent research in hematological and neurological disorders are reviewed, suggesting that ankyrins have a role in the development of human disease.
本综述的重点是锚蛋白基因家族，它是多种组织和多细胞生物中血影蛋白膜骨架与质膜相互作用的关键元件。本文综述了锚蛋白分子的结构/功能关系，阐明了这些蛋白质如何特别适合作为膜骨架与多种整合膜蛋白之间的衔接子。文中讨论了在大脑中对锚蛋白生物学理解的进展，并以此说明锚蛋白如何可能参与特化质膜结构域的建立和/或维持。最后，综述了血液学和神经学疾病的最新研究，提示锚蛋白在人类疾病的发生中起作用。
