Ovesen P, Møller J, Jørgensen J O, Møller N, Christiansen J S
Department of Gynecology and Obstetrics Y, Aarhus Kommunehopital, Denmark.
Fertil Steril. 1993 Feb;59(2):311-4. doi: 10.1016/s0015-0282(16)55709-4.
To evaluate the effects of pharmacological growth hormone (GH) administration on the secretion of pituitary and gonadal hormones during the menstrual cycle in normal women.
Randomized, double-blind, placebo-controlled crossover design.
PATIENTS, PARTICIPANTS: Six normally menstruating, healthy women, 22 to 24 years of age and with a normal body mass index.
Each participant was treated with placebo and growth hormone (12 IU/d) during two different 14-day periods, separated by a 6-week washout period.
Serum insulin-like growth factor I (IGF-I), estradiol, progesterone, follicle-stimulating hormone, and luteinizing hormone.
Administration of GH for 14 days resulted in a significant increase in serum IGF-I, whereas no changes occurred in gonadotropin or sex steroid response.
Growth hormone treatment during the first 14 days of menstrual cycle in normal women does not affect gonadotropin or sex steroid patterns.
评估正常女性月经周期中给予药理剂量生长激素（GH）对垂体和性腺激素分泌的影响。
随机、双盲、安慰剂对照交叉设计。
患者、参与者：6名月经正常、健康的女性，年龄22至24岁，体重指数正常。
每位参与者在两个不同的14天期间分别接受安慰剂和生长激素（12 IU/天）治疗，中间间隔6周的洗脱期。
血清胰岛素样生长因子I（IGF-I）、雌二醇、孕酮、促卵泡激素和促黄体生成素。
给予GH 14天导致血清IGF-I显著升高，而促性腺激素或性类固醇反应无变化。
正常女性月经周期的前14天给予生长激素治疗不影响促性腺激素或性类固醇模式。
