Lipitz S, Rabinovici J, Ben-Shlomo I, Bider D, Ben-Rafael Z, Mashiach S, Dor J
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.
Fertil Steril. 1993 Feb;59(2):348-52. doi: 10.1016/s0015-0282(16)55677-5.
To determine whether complete failure of fertilization of oocytes in couples with unexplained infertility persists during subsequent in vitro fertilization (IVF) cycles.
A retrospective study of 120 cycles of IVF in 44 couples with unexplained infertility and complete failure of fertilization during their first IVF trial.
In vitro fertilization unit of the Sheba Medical Center.
Forty-four couples undergoing IVF for unexplained infertility.
MAIN OUTCOME MEASURE(S): Fertilization rate of retrieved oocytes and pregnancy rate.
Of the initial 44 couples, 37 underwent additional IVF cycles and 30 (81.1%) achieved fertilization. Seven patients conceived during the study period as a result of IVF and two conceived spontaneously.
Complete failure of fertilization does not necessarily persist during subsequent IVF cycles. Therefore, at least two more IVF cycles should be attempted before reverting to other therapeutic options. However, although fertilization can be achieved in most couples, the mean oocyte fertilization rate during subsequent cycles in this group is low. This suggests an underlying undiagnosed pathology of oocyte/sperm interaction in some of these patients.
确定不明原因不孕夫妇中卵母细胞完全受精失败在后续体外受精（IVF）周期中是否持续存在。
对44对不明原因不孕且首次IVF试验中完全受精失败的夫妇进行120个IVF周期的回顾性研究。
舍巴医疗中心体外受精科。
44对因不明原因不孕接受IVF的夫妇。
回收卵母细胞的受精率和妊娠率。
最初的44对夫妇中，37对进行了额外的IVF周期，30对（81.1%）实现了受精。7名患者在研究期间因IVF受孕，2名自然受孕。
完全受精失败在后续IVF周期中不一定持续存在。因此，在转向其他治疗方案之前，应至少再尝试两个IVF周期。然而，尽管大多数夫妇能够实现受精，但该组后续周期中卵母细胞的平均受精率较低。这表明这些患者中一些存在潜在的未被诊断的卵母细胞/精子相互作用病理情况。
