Ben-Shlomo I, Bider D, Dor J, Levran D, Mashiach S, Ben-Rafael Z
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.
Fertil Steril. 1992 Jul;58(1):187-9. doi: 10.1016/s0015-0282(16)55158-9.
To assess the predictive value of a failure to fertilize in vitro in couples with sperm abnormalities on future fertility.
Retrospective file review.
In vitro fertilization and embryo transfer (IVF-ET) program in the Sheba Medical Center during the years 1983 to 1990.
Seventy-six couples with sperm abnormalities who had at least one IVF cycle during which fertilization did not occur.
None.
Occurrence of fertilization, percentage of fertilization, and pregnancies in additional IVF-ET cycles.
Of 44 couples who underwent an additional IVF attempt with husband's sperm, 36 (81.2%) fertilized, with a mean fertilization rate of 47.7% +/- 26.6%. Of 17 couples who failed twice, 11 attempted IVF again with husband's sperm and 7 fertilized, with a median rate of 33%. A higher sperm concentration was found on the cycles during which fertilization occurred. Men with single parameter abnormalities did not fertilize better than those with two or three defective parameters.
Failure to fertilize in vitro in couples with male factor infertility does not seem to predict future fertilization in IVF. At least two cycles of IVF should be tried before reverting to other options such as insemination by donor sperm or gamete micromanipulation.
评估精子异常夫妇体外受精失败对未来生育能力的预测价值。
回顾性病历审查。
1983年至1990年期间谢巴医疗中心的体外受精和胚胎移植（IVF-ET）项目。
76对精子异常夫妇，他们至少经历过一次未发生受精的IVF周期。
无。
在额外的IVF-ET周期中受精的发生情况、受精率和妊娠情况。
在44对使用丈夫精子进行额外IVF尝试的夫妇中，36对（81.2%）受精，平均受精率为47.7%±26.6%。在17对两次受精失败的夫妇中，11对再次使用丈夫精子尝试IVF，7对受精，中位数率为33%。在发生受精的周期中发现精子浓度较高。单一参数异常的男性受精情况并不比有两个或三个缺陷参数的男性更好。
男性因素不育夫妇的体外受精失败似乎不能预测IVF未来的受精情况。在转向其他选择（如供体精子授精或配子显微操作）之前，应至少尝试两个周期的IVF。
