Opsahl C A
Am J Physiol. 1977 Mar;232(3):R128-36. doi: 10.1152/ajpregu.1977.232.3.R128.
The role of the sympathetic nervous system in the lateral hypothalamic syndrome of body-weight loss was investigated. Bilateral electrolytic lesions of the lateral hypothalamus (LH) were performed in 90-day-old male albino rats. In experiment 1, the splanchnic nerves were resected at 35 days (right) and 70 days (left) postlesion. In experiment 2, bilateral adrenal demedullations were performed in a second group of rats with LH lesions (LH rats) at 35 days postlesion. The results indicated that lesions of the lateral hypothalamic area lowered body-weight maintenance levels to approximately 87% of nonlesion control values. Bilateral splanchnicetomy produced a significantly greater body-weight loss in nonlesion animals than in LH rats. Following adrenal demedullation, nonlesion rats also reduced body-weight levels whereas LH rats significantly increased weight-maintenance levels. In addition, the adrenal glands of LH rats with sham demedullations weighed significantly more than the adrenals of nonlesion-sham demedullated animals. These data are discussed in relation to metabolic-autonomic mechanisms that may play a role in LH lesion-induced weight loss.
研究了交感神经系统在因下丘脑外侧综合征导致体重减轻中的作用。对90日龄雄性白化大鼠进行双侧下丘脑外侧（LH）电解损伤。在实验1中，在损伤后35天（右侧）和70天（左侧）切断内脏神经。在实验2中，对第二组有LH损伤的大鼠（LH大鼠）在损伤后35天进行双侧肾上腺髓质切除术。结果表明，下丘脑外侧区损伤使体重维持水平降至非损伤对照值的约87%。双侧内脏神经切断术在非损伤动物中导致的体重减轻比LH大鼠更显著。肾上腺髓质切除术后，非损伤大鼠的体重水平也降低，而LH大鼠的体重维持水平显著提高。此外，接受假髓质切除术的LH大鼠的肾上腺重量明显重于接受假髓质切除术的非损伤动物的肾上腺。结合可能在LH损伤诱导的体重减轻中起作用的代谢 - 自主神经机制对这些数据进行了讨论。
