Wood R J, Rolls B J, Ramsay D J
Am J Physiol. 1977 Mar;232(3):R88-92. doi: 10.1152/ajpregu.1977.232.3.R88.
Eight dogs were prepared with bilateral carotid loops and trained to stand quietly in a modified Pavlov stand. In each of the dogs, 0.3, 0.45, and 0.6 M NaCl were infused, split between the two carotids at a rate of 0.6 ml-kg-1-min-1 for 10 min and the effect on drinking assessed. A graded increase in drinking was obtained with increased osmolality of the saline (R = 0.59, N = 32, P less than 0.001). Infusion of 0.3 M NaCl was associated with an increase in jugular venous osmolality, but no significant increase in systemic osmolality. Intravenous infusion of 0.3 M NaCl at 0.6 ml-kg-1-min-1 had no effect on drinking. Intracarotid infusion of 0.3 M sucrose in 0.15 M NaCl stimulated drinking to a similar extent as 0.3 M NaCl, whereas intracarotid 0.3 M urea in 0.15 M NaCl had no effect. Increasing the systemic plasma osmolality by infusing 1.04 M NaCl intravenously stimulated drinking, an effect which was abolished by removing the central osmotic stimulus with intracarotid infusions of water. These results are compatible with a central osmoreceptor theory of thirst.
选用8只狗，制作双侧颈动脉袢，并训练它们安静地站在改良的巴甫洛夫架上。给每只狗分别以0.6 ml·kg⁻¹·min⁻¹的速率在双侧颈动脉分别输注0.3、0.45和0.6 M的氯化钠，持续10分钟，然后评估对饮水的影响。随着盐水渗透压的升高，饮水量呈分级增加（R = 0.59，N = 32，P < 0.001）。输注0.3 M氯化钠会导致颈静脉渗透压升高，但全身渗透压无显著升高。以0.6 ml·kg⁻¹·min⁻¹的速率静脉输注0.3 M氯化钠对饮水无影响。在0.15 M氯化钠中颈动脉内输注0.3 M蔗糖刺激饮水的程度与0.3 M氯化钠相似，而在0.15 M氯化钠中颈动脉内输注0.3 M尿素则无影响。静脉输注1.04 M氯化钠增加全身血浆渗透压会刺激饮水，而通过颈动脉内输注水消除中枢渗透压刺激后，这种作用消失。这些结果与口渴的中枢渗透压感受器理论相符。
