Thrasher T N, Brown C J, Keil L C, Ramsay D J
Am J Physiol. 1980 May;238(5):R333-9. doi: 10.1152/ajpregu.1980.238.5.R333.
The effects of intravenous infusion of hypertonic NaCl, sucrose, glucose, urea, or isotonic NaCl solution on thirst and plasma arginine vasopressin concentration (AVP) were studied in five conscious dogs. The changes in osmolality and sodium concentration of plasma and cerebrospinal fluid (CSF) were measured at the threshold of drinking, or after 45 min if no drinking occurred. Hypertonic NaCl and sucrose stimulated drinking in all dogs and significantly elevated plasma AVP. Equally hypertonic glucose, urea, or isotonic NaCl failed to stimulate any drinking or vasopressin secretion. All hypertonic solutions caused significant and similar increases in the osmolality and sodium concentration of CSF. Plasma osmolality was increased by the hypertonic solutions. Plasma sodium was increased by hypertonic NaCl, decreased by sucrose and glucose, and not changed by urea. Isotonic NaCl had no effect on either plasma or CSF composition. These data are not consistent with either a sodium or an osmoreceptor mechanism located within the blood-brain barrier (BBB) or with a peripheral sodium receptor mechanism. An intracranial osmoreceptor located on the blood side of the BBB is proposed to explain these results.
在五只清醒的狗身上研究了静脉输注高渗氯化钠、蔗糖、葡萄糖、尿素或等渗氯化钠溶液对口渴和血浆精氨酸加压素浓度（AVP）的影响。在饮水阈值时，或如果没有饮水发生则在45分钟后，测量血浆和脑脊液（CSF）的渗透压和钠浓度变化。高渗氯化钠和蔗糖刺激所有狗饮水，并显著提高血浆AVP。等渗的葡萄糖、尿素或等渗氯化钠未能刺激任何饮水或加压素分泌。所有高渗溶液均导致CSF的渗透压和钠浓度显著且相似地升高。高渗溶液使血浆渗透压升高。高渗氯化钠使血浆钠升高，蔗糖和葡萄糖使其降低，尿素使其不变。等渗氯化钠对血浆或CSF成分均无影响。这些数据与位于血脑屏障（BBB）内的钠或渗透压感受器机制以及外周钠受体机制均不一致。有人提出位于BBB血侧的颅内渗透压感受器来解释这些结果。
