Schneider N G, Popek P, Jarvik M E, Gritz E R
Am J Psychiatry. 1977 Apr;134(4):439-40. doi: 10.1176/ajp.134.4.439.
The authors present three case studies which suggest that smoking withdrawal symptoms in certain individuals may be due to removal of nicotine per se, implying that smokers may develop a true physical dependence on cigarettes. Nicotine replacement by use of an experimental chewing gum containing nicotine in various dosages successfully prevented or alleviated the abstinence symptoms of the subjects studied.
作者们展示了三个案例研究，这些研究表明某些个体的戒烟症状可能是由于尼古丁本身被去除，这意味着吸烟者可能对香烟产生真正的身体依赖。使用含有不同剂量尼古丁的实验性口香糖进行尼古丁替代，成功预防或缓解了所研究对象的戒断症状。
