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在大鼠角叉菜胶水肿模型中，地塞米松的局部抗炎作用被抗脂皮质素1抗血清逆转。

The local anti-inflammatory action of dexamethasone in the rat carrageenin oedema model is reversed by an antiserum to lipocortin 1.

作者信息

Duncan G S, Peers S H, Carey F, Forder R, Flower R J

机构信息

Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London.

出版信息

Br J Pharmacol. 1993 Jan;108(1):62-5. doi: 10.1111/j.1476-5381.1993.tb13440.x.

DOI:10.1111/j.1476-5381.1993.tb13440.x
PMID:8428215
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1907732/
Abstract
  1. A local pre-injection of 1 micrograms dexamethasone sodium phosphate strongly inhibited (> 60% inhibition at 3 h; P < 0.001 at all time points) the development of carrageenin-induced paw oedema in the rat induced by a subplantar injection of 0.1 ml, 2% carrageenin. 2. Coinjection of a polyclonal rabbit antiserum raised against human 1-188 recombinant lipocortin 1, which also recognised the rat protein, reversed the inhibitory action of dexamethasone (P < 0.05 at 4 h and 5 h). At the highest volume used (40 microliters) control antisera were without any effect. 3. These data further support the concept that lipocortin 1 is involved in the anti-inflammatory mechanism of action of the glucocorticoids.
摘要
  1. 预先在局部注射1微克地塞米松磷酸钠，能强烈抑制（3小时时抑制率>60%；所有时间点P<0.001）由足底皮下注射0.1毫升2%角叉菜胶诱导的大鼠角叉菜胶性爪肿胀的发展。2. 同时注射针对人1-188重组脂皮质素1产生的多克隆兔抗血清（该抗血清也能识别大鼠蛋白），可逆转地塞米松的抑制作用（4小时和5小时时P<0.05）。在使用的最大体积（40微升）下，对照抗血清无任何作用。3. 这些数据进一步支持了脂皮质素1参与糖皮质激素抗炎作用机制的概念。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37dc/1907732/697b178fdd14/brjpharm00207-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37dc/1907732/697b178fdd14/brjpharm00207-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37dc/1907732/697b178fdd14/brjpharm00207-0069-a.jpg

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The local anti-inflammatory action of dexamethasone in the rat carrageenin oedema model is reversed by an antiserum to lipocortin 1.在大鼠角叉菜胶水肿模型中，地塞米松的局部抗炎作用被抗脂皮质素1抗血清逆转。
Br J Pharmacol. 1993 Jan;108(1):62-5. doi: 10.1111/j.1476-5381.1993.tb13440.x.
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Proc Natl Acad Sci U S A. 1989 May;86(9):3428-32. doi: 10.1073/pnas.86.9.3428.
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Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1.内源性和外源性脂皮质素1对中性粒细胞和单核细胞募集的抑制作用。
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The role of lipocortin-1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse.脂皮质素-1在小鼠皮肤炎症反应中地塞米松对嗜酸性粒细胞迁移的抑制作用中的作用。
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Dexamethasone suppresses the release of prolactin from the rat anterior pituitary gland by lipocortin 1 dependent and independent mechanisms.地塞米松通过脂皮质素1依赖和非依赖机制抑制大鼠垂体前叶催乳素的释放。
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本文引用的文献

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A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.糖皮质激素诱导的兔中性粒细胞中的一种磷脂酶A2抑制蛋白。
Proc Natl Acad Sci U S A. 1980 May;77(5):2533-6. doi: 10.1073/pnas.77.5.2533.
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The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats.蛋白酪氨酸激酶底物p36（钙结合蛋白I重链）的cDNA序列显示该蛋白是一种具有内部重复序列的多结构域蛋白。
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Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.
膜联蛋白I和环氧化酶-2在无烟烟草诱导的炎症和口腔癌中的调节作用
Mol Cell Biochem. 2003 Jun;248(1-2):67-75. doi: 10.1023/a:1024153431272.
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Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes.膜联蛋白I和地塞米松对人滑膜细胞中磷脂酶和环氧化酶活性的影响。
Mediators Inflamm. 2000;9(3-4):125-32. doi: 10.1080/09629350020018357.
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Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1.脂皮质素1对小胶质细胞环氧化酶-2和诱导型一氧化氮合酶表达的下调作用
Br J Pharmacol. 1999 Mar;126(6):1307-14. doi: 10.1038/sj.bjp.0702423.
6
Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat.膜联蛋白-1对大鼠实验性自身免疫性脑脊髓炎（EAE）的影响。
Clin Exp Immunol. 1998 Jan;111(1):198-204. doi: 10.1046/j.1365-2249.1998.00490.x.
7
Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1.小鼠的急性炎症反应：脂皮质素1免疫中和作用导致炎症加剧。
Br J Pharmacol. 1996 Mar;117(6):1145-54. doi: 10.1111/j.1476-5381.1996.tb16709.x.
8
Translocation of lipocortin (annexin) 1 to the membrane of U937 cells induced by phorbol ester, but not by dexamethasone.佛波酯可诱导脂皮质素（膜联蛋白）1转位至U937细胞膜，但地塞米松则不能。
Br J Pharmacol. 1996 Apr;117(8):1780-4. doi: 10.1111/j.1476-5381.1996.tb15354.x.
9
Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat.脂皮质素1介导地塞米松对大鼠体内内毒素诱导一氧化氮合酶的抑制作用。
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3473-7. doi: 10.1073/pnas.92.8.3473.
五种不同的钙结合蛋白和磷脂结合蛋白与脂皮质素I具有同源性。
J Biol Chem. 1988 Aug 5;263(22):10799-811.
4
Human recombinant lipocortin 1 inhibits prostacyclin production by human umbilical artery in vitro.人重组脂皮质素1在体外可抑制人脐动脉生成前列环素。
Prostaglandins. 1987 Jul;34(1):59-62. doi: 10.1016/0090-6980(87)90262-0.
5
Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung.重组人脂皮质素1抑制豚鼠离体灌注肺释放血栓素。
Nature. 1987;328(6127):270-2. doi: 10.1038/328270a0.
6
The presence of lipocortin in human embryonic skin fibroblasts and its regulation by anti-inflammatory steroids.脂皮质素在人胚胎皮肤成纤维细胞中的存在及其受抗炎类固醇的调节。
Biochim Biophys Acta. 1985 Nov 20;847(2):247-54. doi: 10.1016/0167-4889(85)90027-8.
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Somatostatin gene expression in the thymus gland.胸腺中生长抑素基因的表达。
J Immunol. 1989 Aug 1;143(3):1015-7.
8
Lipocortin-independent effect of dexamethasone on phospholipase activity in a thymic epithelial cell line.地塞米松对胸腺上皮细胞系中磷脂酶活性的不依赖脂皮质素的作用
Biochem J. 1989 Jul 15;261(2):395-400. doi: 10.1042/bj2610395.
9
Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test.人重组脂皮质蛋白1在大鼠足爪水肿试验中具有急性局部抗炎特性。
Proc Natl Acad Sci U S A. 1989 May;86(9):3428-32. doi: 10.1073/pnas.86.9.3428.
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Characteristics of lipocortin 1 binding to the surface of human peripheral blood leucocytes.脂皮质素1与人类外周血白细胞表面结合的特性
Biochem Soc Trans. 1990 Dec;18(6):1237-8. doi: 10.1042/bst0181237.