Windsor A C, Mullen P G, Fowler A A, Sugerman H J
Department of Surgery, Medical College of Virginia, Richmond 23298-0519.
Br J Surg. 1993 Jan;80(1):10-7. doi: 10.1002/bjs.1800800106.
Adult respiratory distress syndrome (ARDS) remains a significant cause of morbidity and mortality in surgical practice. Despite the continued advance of surgical technique and therapy, the mainstay of treatment of ARDS remains supportive. In the past decade cytokines have been found to be primary chemical mediators of the host response to inflammatory disease. The polymorphonuclear leucocyte has also emerged as a possible cellular mediator of the end-organ damage that characterizes these inflammatory processes. The role of the neutrophil as the primary cellular mediator of alveolar capillary membrane injury in ARDS remains controversial. This article reviews the relevant current literature and considers the implications of the prevailing evidence on future management of this syndrome.
成人呼吸窘迫综合征（ARDS）仍是外科手术中发病和死亡的重要原因。尽管外科技术和治疗方法不断进步，但ARDS的主要治疗手段仍是支持治疗。在过去十年中，细胞因子已被发现是宿主对炎症性疾病反应的主要化学介质。多形核白细胞也已成为这些炎症过程中特征性终末器官损伤的一种可能的细胞介质。中性粒细胞作为ARDS中肺泡毛细血管膜损伤的主要细胞介质的作用仍存在争议。本文回顾了当前的相关文献，并考虑了现有证据对该综合征未来治疗的影响。
