Wong P T, Goldstein S M, Grekin R C, Godwin T A, Pivik C, Rigas B
Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario.
Cancer Res. 1993 Feb 15;53(4):762-5.
Infrared spectroscopy combined with high pressure (pressure-tuning infrared spectroscopy) was applied to the study of paired sections of basal cell carcinomas (BCC) and normal skin from ten patients. Atmospheric pressure IR spectra from BCC were dramatically different from those from the corresponding normal skin. Compared to their normal controls, BCCs displayed increased hydrogen bonding of the phosphodiester group of nucleic acids, decreased hydrogen bonding of the C--OH groups of proteins, increased intensity of the band at 972 cm-1, a decreased intensity ratio between the CH3 stretching and CH2 stretching bands, and accumulation of unidentified carbohydrates. Some of these changes are shared by all human epithelial malignancies studied to date, while some others appear as yet unique to basal cell carcinoma. The diagnostic value of infrared spectroscopy in BCC remains to be determined.
将红外光谱与高压相结合（压力调谐红外光谱）应用于对10名患者的基底细胞癌（BCC）和正常皮肤配对切片的研究。BCC的大气压红外光谱与相应正常皮肤的光谱显著不同。与正常对照相比，BCC显示核酸磷酸二酯基团的氢键增加、蛋白质C-OH基团的氢键减少、972 cm-1处谱带强度增加、CH3伸缩带与CH2伸缩带的强度比降低以及未鉴定碳水化合物的积累。其中一些变化是迄今为止所有已研究的人类上皮恶性肿瘤所共有的，而其他一些变化似乎是基底细胞癌所特有的。红外光谱在BCC中的诊断价值仍有待确定。
