Khanna J M, Shah G, Weiner J, Wu P H, Kalant H
Department of Pharmacalogy, University of Toronto, Ont., Canada.
Eur J Pharmacol. 1993 Jan 5;230(1):23-31. doi: 10.1016/0014-2999(93)90405-7.
Hypothermia and motor impairment (tilt-plane test) were used to assess whether N-methyl-D-aspartate (NMDA) receptors play a role in the development of rapid tolerance to ethanol, i.e., tolerance to a second dose of ethanol given 24 h after the effect of the first dose of ethanol had disappeared. Results showed that (+)-MK-801 and ketamine blocked the development of rapid tolerance to ethanol on both tests. Since these drugs did not modify blood or brain alcohol levels in any of the groups, the blockade of ethanol rapid tolerance cannot be attributed to changes in pharmacokinetics of ethanol. These data suggest that the role of NMDA receptors in ethanol tolerance may be similar to their role in memory and learning, involving a facilitation of transmission in certain synapses.
体温过低和运动障碍（倾斜平面试验）被用于评估N-甲基-D-天冬氨酸（NMDA）受体是否在对乙醇快速耐受性的形成中发挥作用，即对在第一剂乙醇作用消失24小时后给予的第二剂乙醇的耐受性。结果显示，（+）-MK-801和氯胺酮在两项试验中均阻断了对乙醇快速耐受性的形成。由于这些药物在任何组中均未改变血液或脑内乙醇水平，因此乙醇快速耐受性的阻断不能归因于乙醇药代动力学的变化。这些数据表明，NMDA受体在乙醇耐受性中的作用可能与其在记忆和学习中的作用相似，涉及某些突触中传递的促进作用。
