Rastogi A, Singh V K, Biswas S, Haq W, Mathur K B, Agarwal S S
Division of Biopolymers, Central Drug Research Institute, Lucknow, India.
FEBS Lett. 1993 Feb 8;317(1-2):93-5. doi: 10.1016/0014-5793(93)81498-o.
Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg-D-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr (2), D-Lys-Lys-Glu-Val-Tyr (3), Arg-Lys-Gly-Val-Tyr (4), and Arg-Lys-Gln-Val-Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.
