Kelly J D, Forster A M, Higley B, Archer C M, Booker F S, Canning L R, Chiu K W, Edwards B, Gill H K, McPartlin M
Pharmaceuticals Research and Development, Amersham International plc, Buckinghamshire, United Kingdom.
J Nucl Med. 1993 Feb;34(2):222-7.
A new cationic complex, [99mTc(tetrofosmin)2O2]+, where tetrofosmin is the ether functionalized diphosphine ligand 1,2-bis[bis(2-ethoxyethyl)phosphino]ethane, has been synthesized and evaluated for potential use in myocardial perfusion imaging. The structure of the complex has been determined by x-ray crystallography of the 99Tc analog. In comparison with previously reported 99mTc complexes of alkyl-phosphines, the tetrofosmin species shows substantially increased clearance from nontarget tissue, especially blood and liver. A freeze-dried kit formulation has been developed. The kit provides a product of high radiochemical purity up to 8 hr after reconstitution at room temperature.
一种新的阳离子配合物[99mTc(四磷酰胺)2O2]+已被合成并评估其在心肌灌注成像中的潜在应用，其中四磷酰胺是醚官能化的二膦配体1,2-双[双(2-乙氧基乙基)膦基]乙烷。该配合物的结构已通过99Tc类似物的x射线晶体学确定。与先前报道的烷基膦的99mTc配合物相比，四磷酰胺类物质从非靶组织，尤其是血液和肝脏中的清除率显著提高。已开发出冻干试剂盒配方。该试剂盒在室温下复溶后8小时内提供高放射化学纯度的产品。
