MMWR Morb Mortal Wkly Rep. 1993 Feb 5;42(4):74-5, 81.
Patients with tuberculosis (TB) who fail to complete a standard course of antituberculosis (anti-TB) therapy are at increased risk for treatment failure and may play a role in both the emergence of drug-resistant strains of Mycobacterium tuberculosis and further spread of TB. During 1986-1991, the South Carolina Department of Health and Environmental Control and the New York City Department of Health (NYCDH) attempted to improve patient adherence to anti-TB therapy by employing a combination of strategies that included incentives, directly observed therapy (DOT) (i.e., health-care worker observation of the patient ingesting each dose of medication), court-ordered DOT, and commitment for inpatient management. This report describes the experiences of selected strategies in South Carolina and New York City and provides recommendations for improving patient adherence to anti-TB therapy.
未完成标准抗结核治疗疗程的结核病患者治疗失败风险增加，可能在结核分枝杆菌耐药菌株的出现以及结核病的进一步传播中起作用。1986年至1991年期间，南卡罗来纳州卫生与环境控制部以及纽约市卫生部（NYCDH）试图通过采用包括激励措施、直接观察治疗（DOT）（即医护人员观察患者服用每一剂药物）、法庭命令的DOT以及住院管理承诺在内的一系列策略组合来提高患者对抗结核治疗的依从性。本报告描述了南卡罗来纳州和纽约市选定策略的经验，并为提高患者对抗结核治疗的依从性提供建议。
