Valji K, Bookstein J J
Department of Radiology, University of California, San Diego 92103.
Radiology. 1993 Mar;186(3):873-6. doi: 10.1148/radiology.186.3.8430201.
The effects of intrathrombic and intravenous injection of prostaglandin E1 (PGE1) during pulse-spray thrombolysis were studied in a rabbit model. Thrombi were produced in the inferior vena cava of 46 rabbits by means of vessel wall injury and placement of steel coils. At 2 days, pulse-spray thrombolysis was performed by using a catheter with multiple side holes spanning the clot. A control group received injections of saline. In all other rabbits, 3 mg of tissue-type plasminogen activator (tPA) was injected into the thrombus over 1 hour, and 500 U of heparin was intravenously administered. PGE1 was administered either intravenously (50 micrograms) or directly into the thrombus (10, 25, or 50 micrograms) in four groups. After treatment, the rabbits were killed and the residual clot was weighed. The relationship between clot length and volume measured on angiograms and clot weight was assessed in 13 additional untreated rabbits. Linear regression analysis was used to estimate the initial clot weight on the basis of measured clot length in treated animals. The extent of clot lysis was significantly greater with injection of tPA and 10-, 25-, or 50-micrograms PGE1 directly into the thrombous than with administration of tPA alone.
在兔模型中研究了脉冲喷射溶栓期间经血栓内和静脉注射前列腺素E1（PGE1）的效果。通过血管壁损伤和放置钢圈在46只兔的下腔静脉中形成血栓。在第2天，使用带有多个横跨血栓侧孔的导管进行脉冲喷射溶栓。对照组注射生理盐水。在所有其他兔中，在1小时内将3mg组织型纤溶酶原激活剂（tPA）注入血栓，并静脉给予500U肝素。四组兔分别经静脉给予PGE1（50μg）或直接注入血栓（10、25或50μg）。治疗后，处死兔并对残余血栓称重。在另外13只未经治疗的兔中评估血管造影测量的血栓长度和体积与血栓重量之间的关系。使用线性回归分析根据治疗动物中测量的血栓长度估计初始血栓重量。与单独给予tPA相比，将tPA与10、25或50μg PGE1直接注入血栓时，血栓溶解程度明显更大。
