Wang X D, Ar'Rajab A, Andersson R, Soltesz V, Wang W, Svensson M, Bengmark S
Dept. of Surgery, Lund University, Sweden.
Scand J Gastroenterol. 1993 Jan;28(1):31-40. doi: 10.3109/00365529309096042.
The influence of acute liver failure induced by 90% hepatectomy on the intestine was evaluated in the rat. Small-intestinal mucosal mass decreased 2 h after hepatectomy. Microvillous height decreased significantly from 1 h and on, and villous height and area in the distal small intestine from 2 h after operation. Ninety per cent hepatectomy resulted in a decrease in systemic arterial blood pressure and an increase in portal venous pressure. Subserosal microcirculation and small-arterial circulation in the proximal and distal small intestine and colon decreased significantly after 90% hepatectomy. Overgrowth and colonization of Escherichia coli occurred in the distal small intestine from 1 h and on after hepatectomy. Protein content in enterocytes and bile secretion from the liver remnant were markedly reduced in hepatectomized rats. Thus, the present study shows evidence of alterations in intestinal morphology and function that can contribute to explain the enteric bacterial translocation after surgically induced acute liver failure.
在大鼠中评估了90%肝切除诱导的急性肝衰竭对肠道的影响。肝切除术后2小时小肠黏膜质量下降。微绒毛高度从术后1小时开始显著降低，术后2小时起远端小肠的绒毛高度和面积减小。90%肝切除导致体循环动脉血压降低和门静脉压力升高。90%肝切除术后，近端和远端小肠及结肠的浆膜下微循环和小动脉循环显著减少。肝切除术后1小时起，远端小肠出现大肠杆菌过度生长和定植。肝切除大鼠肠上皮细胞中的蛋白质含量和肝残余组织的胆汁分泌明显减少。因此，本研究显示了肠道形态和功能改变的证据，这有助于解释手术诱导的急性肝衰竭后的肠道细菌易位。
