Louis J C, Magal E, Takayama S, Varon S
Department of Biology, University of California, San Diego, La Jolla 92093.
Science. 1993 Jan 29;259(5095):689-92. doi: 10.1126/science.8430320.
A proportion of developing oligodendrocytes undergo natural cell death by apoptosis, and mature oligodendrocytes die, either by apoptosis or necrosis, in response to injurious signals such as cytotoxic cytokines and complement. Ciliary neurotrophic factor (CNTF), a trophic factor found in astrocytes in the central nervous system (CNS), promoted the survival and maturation of cultured oligodendrocytes. This trophic factor also protected oligodendrocytes from death induced by tumor necrosis factors (apoptosis) but not against complement (necrosis). These results suggest that CNTF functions in the survival of oligodendrocytes during development and may lead to therapeutic approaches for degenerative diseases of the CNS that involve oligodendrocyte destruction.
一部分正在发育的少突胶质细胞会通过凋亡自然死亡，而成熟的少突胶质细胞则会因细胞毒性细胞因子和补体等损伤信号，通过凋亡或坏死的方式死亡。睫状神经营养因子（CNTF）是一种在中枢神经系统（CNS）星形胶质细胞中发现的营养因子，它能促进培养的少突胶质细胞的存活和成熟。这种营养因子还能保护少突胶质细胞免受肿瘤坏死因子诱导的死亡（凋亡），但不能抵御补体诱导的死亡（坏死）。这些结果表明，CNTF在少突胶质细胞发育过程中的存活中发挥作用，并且可能会为涉及少突胶质细胞破坏的中枢神经系统退行性疾病带来治疗方法。
