Paracetamol estimation: comparison of a quick colorimetric method with a standard spectrophotometric method.

A new colorimetric method for the estimation of plasma paracetamol was slightly modified and compared with a standard spectrophotometric method. Good correlation and no significant difference was found between results by the two procedures. Precision, accuracy, and recovery by the colorimetric method were acceptable. On the other hand it is less susceptible than the spectrophotometric method to interference by certain other drugs. The speed and simplicity of the colorimetric method, together with its satisfactory performance, make it a worthwile alternative to the spectrophotometric procedure.