Katsunuma T, Hashimoto K, Akimoto K, Ebisawa M, Iikura Y
Department of Allergy, National Children's Hospital, Tokyo, Japan.
Ann Allergy. 1993 Feb;70(2):165-70.
We investigated the effect of 300 micrograms of inhaled beclomethasone dipropionate (BDP) daily on bronchial responsiveness to methacholine and pulmonary function of 22 subjects with asthma in a single-blind, crossover study. The severity of bronchial hyperresponsiveness lessened significantly during treatment with BDP (P < .01). No significant changes occurred in FEV1 or in the control value of airway conductance. We conclude that a 300-micrograms total daily dose of BDP is an efficacious treatment for patients with asthma. Because suppression of adrenal function and systemic adverse effects can occur in asthmatic patients treated with inhaled corticosteroids, especially children, long-term treatment with inhaled steroids should employ minimal daily doses necessary.
在一项单盲交叉研究中，我们调查了每日吸入300微克二丙酸倍氯米松（BDP）对22名哮喘患者支气管对乙酰甲胆碱的反应性及肺功能的影响。在使用BDP治疗期间，支气管高反应性的严重程度显著减轻（P <.01）。第一秒用力呼气容积（FEV1）或气道传导控制值未发生显著变化。我们得出结论，每日300微克的BDP总剂量对哮喘患者是一种有效的治疗方法。由于吸入皮质类固醇治疗的哮喘患者，尤其是儿童，可能会出现肾上腺功能抑制和全身不良反应，长期吸入类固醇治疗应采用必要的最小日剂量。
