Binder S, Le N B, Berner H, Bauer J
Lehrstuhl für Tierhygiene, Technischen Universität München in Weihenstephan.
Berl Munch Tierarztl Wochenschr. 1993 Jan;106(1):6-9.
Within the scope of the clinical evaluation of Tilmicosin in Enzootic Pneumonia of pigs, nasal swabs from 78 animals were taken, before and after oral medication of different doses (0, 100, 200, 300 mg Tilmicosin/kg dry food), and examined bacteriologically for Pasteurella multocida, Bordetella bronchiseptica und Haemophilus parasuis. The bacteria aforementioned were isolated from the nasal secretions of 83% of the pigs, 14 days after crowding without any prophylactic regime. It could be demonstrated, that pigs with clinical symptoms of Enzootic Pneumonia had a 50% higher prevalence-rate of multi-colonization with pneumotropic bacteria than healthy animals. Feeding 300 mg Tilmicosin/kg food for 9 and 14 days respectively, resulted in elimination of Pasteurella spp. and Haemophilus spp. The rate of newly Bordetella bronchiseptica infected pigs was lower than in the placebo-group. Parallel to these bacteriological results improvement of clinical signs and increased daily weight gain were observed.
在替米考星对猪地方流行性肺炎临床评估的范围内，在不同剂量（0、100、200、300毫克替米考星/千克干粮）口服给药前后，采集了78头动物的鼻拭子，并对多杀性巴氏杆菌、支气管败血波氏杆菌和副猪嗜血杆菌进行了细菌学检测。在没有任何预防措施的情况下拥挤饲养14天后，上述细菌从83%的猪的鼻分泌物中分离出来。可以证明，有地方流行性肺炎临床症状的猪感染嗜肺性细菌的多重定植患病率比健康动物高50%。分别以300毫克替米考星/千克饲料喂养9天和14天，可导致巴氏杆菌属和嗜血杆菌属被清除。新感染支气管败血波氏杆菌的猪的比例低于安慰剂组。与这些细菌学结果平行，观察到临床症状改善和日增重增加。
