Moore G M, Basson R P, Tonkinson L V
Elanco Animal Health Animal Science Field Development Research, Eli Lilly and Co, Greenfield, IN 46140, USA.
Am J Vet Res. 1996 Feb;57(2):224-8.
To determine and evaluate the efficacy of the dose range of tilmicosin phosphate fed to pigs for control of pneumonia attributable to Actinobacillus pleuropneumoniae during episodes of clinical disease in commercial herds.
12 trials were run in 9 geographic locations in herds with a history of pneumonia caused by A pleuropneumoniae.
Clinically normal male and female pigs of various body weights.
Two doses of tilmicosin phosphate (200 and 400 micrograms/g) and a 0 dose were administered in the feed for 21 days. Variables for determining efficacy were daily independent composite clinical impression score, individual pig weight, mortality, percentage of pneumonic involvement, and frequency of isolation of bacterial pathogens.
Medicated pigs had significantly lower mortality attributed to pneumonia than did nonmedicated pigs. In trials with confirmed pneumonia caused by A pleuropneumoniae or Pasteurella multocida, weight gain, feed conversion, and clinical impression scores were significantly improved in the pigs receiving 200 or 400 micrograms/g of tilmicosin, compared with nonmedicated pigs.
The clinical field trials reported here confirm that tilmicosin in the feed at 200 micrograms/g is effective for control of swine pneumonia attributable to A pleuropneumoniae or P multocida.
Under the moderate natural challenge conditions encountered, tilmicosin at 400 micrograms/g was not different from tilmicosin at 200 micrograms/g.
确定并评估在商品猪群临床疾病发作期间，给猪投喂不同剂量的磷酸替米考星以控制由胸膜肺炎放线杆菌引起的肺炎的疗效。
在9个地理位置有胸膜肺炎放线杆菌引起的肺炎病史的猪群中进行了12项试验。
各种体重的临床健康的雄性和雌性猪。
在饲料中分别添加两种剂量的磷酸替米考星（200和400微克/克）以及0剂量（不添加），持续投喂21天。用于确定疗效的变量包括每日独立综合临床印象评分、个体猪体重、死亡率、肺部感染百分比以及细菌病原体分离频率。
用药猪因肺炎导致的死亡率显著低于未用药猪。在由胸膜肺炎放线杆菌或多杀性巴氏杆菌引起的确诊肺炎的试验中，与未用药猪相比，接受200或400微克/克替米考星的猪的体重增加、饲料转化率和临床印象评分均有显著改善。
此处报告的临床现场试验证实，饲料中200微克/克的替米考星对控制由胸膜肺炎放线杆菌或多杀性巴氏杆菌引起的猪肺炎有效。
在遇到的中等自然挑战条件下，400微克/克的替米考星与200微克/克的替米考星效果无异。
