Alcock R, Peachey T, Lynch M, McEwan T
Department of Anaesthetics, Eastman Dental Hospital, London.
Br J Anaesth. 1993 Jan;70(1):34-7. doi: 10.1093/bja/70.1.34.
We have performed a prospective study in 100 adults (ASA I or II) undergoing day-case dental extraction to compare the conditions for intubation and the postoperative sequelae of suxamethonium and alfentanil as adjuncts to propofol. The patients were allocated randomly to two groups comparable in age, sex and weight. Successful intubation was achieved in 100% of the suxamethonium group and 90% of the alfentanil group. Of the patients who received suxamethonium, 74% developed myalgia on the day after surgery, compared with 20% in the alfentanil group (P < 0.001). The proportion of patients who developed sore throat was also less in the alfentanil group than in the suxamethonium group (P < 0.05). The proportion of patients who complained of nausea in the two groups was not significantly different. We conclude that alfentanil, as an adjunct to propofol to facilitate tracheal intubation, is more acceptable to patients than suxamethonium in anaesthesia for day-case surgery.
我们对100例接受日间拔牙的成年患者（ASA I或II级）进行了一项前瞻性研究，以比较使用琥珀胆碱和阿芬太尼作为丙泊酚辅助药物时的插管条件及术后后遗症。患者被随机分为两组，两组在年龄、性别和体重方面具有可比性。琥珀胆碱组的插管成功率为100%，阿芬太尼组为90%。接受琥珀胆碱的患者中，74%在术后第一天出现肌痛，而阿芬太尼组为20%（P<0.001）。阿芬太尼组出现咽痛的患者比例也低于琥珀胆碱组（P<0.05）。两组中抱怨恶心的患者比例无显著差异。我们得出结论，在日间手术麻醉中，阿芬太尼作为丙泊酚辅助药物以促进气管插管，比琥珀胆碱更易为患者所接受。
