Watanabe H, Lindgren L, Rosenberg P, Randell T
Department of Anesthesiology, Sapporo Medical College, Japan.
Br J Anaesth. 1993 Jan;70(1):94-5. doi: 10.1093/bja/70.1.94.
We have studied the effect of glycopyrronium on the anaesthetic action and absorption of topical lignocaine in 10 healthy, non-smoking volunteers. Lignocaine 100 mg was sprayed on the oral mucosa 15 min after random administration of glycopyrronium 4 micrograms kg-1 or normal saline i.v. Glycopyrronium decreased the mean analgesia score from 2 to 0.1 (2 = baseline; 0 = anaesthesia) at 4 min compared with a change from 2 to 0.5 after normal saline (P < 0.05). All scores returned to baseline by 40 min and 20 min in the glycopyrronium and control groups, respectively. The mean (SD) peak plasma lignocaine concentration was 0.57 (0.29) microgram ml-1 after glycopyrronium and 0.31 (0.10) microgram ml-1 after saline (P < 0.05) and were attained in 17 min (range 10-40 min) and 29 min (range 8-40 min), respectively. Pretreatment with glycopyrronium enhanced absorption and prolonged the analgesic action of topically administered lignocaine.
我们研究了格隆溴铵对10名健康、不吸烟志愿者局部利多卡因麻醉作用及吸收的影响。在静脉随机给予4微克/千克格隆溴铵或生理盐水15分钟后，将100毫克利多卡因喷于口腔黏膜。与生理盐水组给药后疼痛评分从2降至0.5相比，格隆溴铵组给药后4分钟时平均镇痛评分从2降至0.1（2为基线值；0为麻醉状态）（P<0.05）。格隆溴铵组和对照组分别在40分钟和20分钟时所有评分均恢复至基线值。格隆溴铵组利多卡因血浆峰浓度均值（标准差）为0.57（0.29）微克/毫升，生理盐水组为0.31（0.10）微克/毫升（P<0.05），分别在17分钟（范围10 - 40分钟）和29分钟（范围8 - 40分钟）达到峰浓度。预先使用格隆溴铵可增强局部应用利多卡因的吸收并延长其镇痛作用。
