Sier C F, Verspaget H W, Griffioen G, Ganesh S, Vloedgraven H J, Lamers C B
Department of Gastroenterology and Hepatology, University Hospital Leiden, The Netherlands.
Gut. 1993 Jan;34(1):80-5. doi: 10.1136/gut.34.1.80.
Carcinogenesis in the human colon is associated with a marked increase of urokinase type plasminogen activator and a decrease of tissue type plasminogen activator. This study was performed to determine the concentrations of urokinase type plasminogen activator and tissue type plasminogen activator in normal tissue and carcinomas along the upper part of the gastrointestinal tract. Activity and antigen levels of both activators were determined in homogenates of endoscopically obtained biopsies from normal and carcinomatous tissues. Although the concentrations of tissue type plasminogen activator and urokinase type plasminogen activator in normal squamous epithelium of the oesophagus were low compared with those in columnar epithelium from the stomach, the urokinase type plasminogen activator/tissue type plasminogen activator antigen ratio of the different locations showed hardly any difference. Significant but heterogeneous increases were found in urokinase type plasminogen activator concentrations of biopsy specimens originating from carcinomas of both epithelial cell types. A decrease in tissue type plasminogen activator concentrations, as found in human colon carcinomas, could only be shown in carcinomas of columnar epithelium origin but not in squamous cell carcinomas of the oesophagus. The increase of urokinase type plasminogen activator and urokinase type plasminogen activator/tissue type plasminogen activator antigen ratio and the decrease of tissue type plasminogen activator in the carcinomas did not show a significant correlation with known prognostic determinants as differentiation grade, TNM classification, intestinal metaplasia, inflammation, and ulceration. The heterogeneous increase of urokinase type plasminogen activator in oesophageal and stomach carcinomas, together with the recently described association of urokinase type plasminogen activator in tissue extracts of breast carcinomas with aggressiveness and prognosis, may be relevance to prognostic studies, may be of relevance to prognostic studies in oesophageal and gastric cancer.
人类结肠癌的发生与尿激酶型纤溶酶原激活物显著增加及组织型纤溶酶原激活物减少有关。本研究旨在测定上消化道正常组织和癌组织中尿激酶型纤溶酶原激活物和组织型纤溶酶原激活物的浓度。通过对正常组织和癌组织的内镜活检匀浆进行检测，确定两种激活物的活性和抗原水平。尽管与胃柱状上皮相比，食管正常鳞状上皮中组织型纤溶酶原激活物和尿激酶型纤溶酶原激活物的浓度较低，但不同部位的尿激酶型纤溶酶原激活物/组织型纤溶酶原激活物抗原比值几乎没有差异。在两种上皮细胞类型癌的活检标本中，尿激酶型纤溶酶原激活物浓度均有显著但不均匀的增加。如在人类结肠癌中发现的组织型纤溶酶原激活物浓度降低，仅在柱状上皮起源的癌中出现，而在食管鳞状细胞癌中未出现。癌组织中尿激酶型纤溶酶原激活物及其与组织型纤溶酶原激活物抗原比值的增加以及组织型纤溶酶原激活物的减少，与分化程度、TNM分类、肠化生、炎症和溃疡等已知预后决定因素均无显著相关性。食管和胃癌中尿激酶型纤溶酶原激活物的不均匀增加，以及最近报道的乳腺癌组织提取物中尿激酶型纤溶酶原激活物与侵袭性和预后的关联，可能与食管和胃癌的预后研究相关。
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