Szczepański M, Lucer C, Zawadzki J, Tołłoczko T
Int J Cancer. 1982 Sep 15;30(3):329-33. doi: 10.1002/ijc.2910300312.
Procoagulant activity (PA) and fibrinolytic activity (FA) were investigated in 14 specimens of gastric cancer (GC) and in 26 specimens of colorectal cancer (CC) and simultaneously, in samples of the normal mucosa obtained from the same organs. Histochemical localization of plasminogen activator was performed at the tumor borderline. The PA of the tumor extracts was in most cases lower than in the corresponding normal mucosa from GC as well as CC patients. The FA of the extracts of CC was also lower than that of normal mucosa. On the other hand, 11 of 14 cases with GC showed a significantly higher FA in the tumor extracts than that in the corresponding normal mucosa. The histochemical localization of plasminogen activator revealed that its activity is connected with small and medium-sized blood vessels, but not with the cells of the two kinds of cancer investigated. Morphological and histochemical findings from both kinds of cancer demonstrate that the FA of their extracts depends on the vascularity of specimens of the respective tumors.
对14例胃癌（GC）标本和26例结直肠癌（CC）标本以及同时从相同器官获取的正常黏膜样本进行了促凝活性（PA）和纤溶活性（FA）研究。在肿瘤边界处进行了纤溶酶原激活剂的组织化学定位。大多数情况下，肿瘤提取物的PA低于GC和CC患者相应的正常黏膜。CC提取物的FA也低于正常黏膜。另一方面，14例GC患者中有11例肿瘤提取物中的FA显著高于相应的正常黏膜。纤溶酶原激活剂的组织化学定位显示其活性与中小血管有关，而与所研究的两种癌症的细胞无关。两种癌症的形态学和组织化学结果表明，其提取物的FA取决于各自肿瘤标本的血管分布。
