Smith K J, Skelton H G, Yeager J, Angritt P, Frisman D, Wagner K F, Baxter D, James W D, Oster C N
Armed Forces Institute of Pathology, Department of Dermatopathology, Washington, DC 20306.
J Am Acad Dermatol. 1993 Feb;28(2 Pt 1):174-84. doi: 10.1016/0190-9622(93)70024-n.
Cutaneous lesions are common in patients with human immunodeficiency virus type 1 (HIV-1) infection. In many cases they are nonspecific inflammatory dermatoses.
Our goal was to determine whether features of these inflammatory dermatoses were characteristic of HIV-1 infection and whether the changes correlated with the stage of disease.
Biopsy specimens of inflammatory dermatoses from 176 HIV-1-infected patients in all Walter Reed stages were reviewed and the changes were compared with each WR stage.
The changes found were nonspecific but were suggestive of features described in graft-versus-host disease and became more prominent in late-stage disease.
A correlation was found between the changes and the stage of disease, and the findings add support to prior reports that at least some of the changes in HIV-1 infection may be autoimmune in origin.
皮肤病变在1型人类免疫缺陷病毒（HIV-1）感染患者中很常见。在许多情况下，它们是非特异性炎症性皮肤病。
我们的目标是确定这些炎症性皮肤病的特征是否为HIV-1感染所特有，以及这些变化是否与疾病阶段相关。
回顾了来自所有沃尔特·里德阶段的176例HIV-1感染患者的炎症性皮肤病活检标本，并将这些变化与每个WR阶段进行了比较。
所发现的变化是非特异性的，但提示了移植物抗宿主病中描述的特征，并且在疾病晚期变得更加明显。
发现这些变化与疾病阶段之间存在相关性，这些发现为先前的报告提供了支持，即HIV-1感染中的至少一些变化可能源于自身免疫。
