Smith K J, Skelton H G, Yeager J, Baxter D, Angritt P, Johnson S, Oster C N, Wagner K F
Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, DC 20306.
J Am Acad Dermatol. 1993 Feb;28(2 Pt 1):167-73. doi: 10.1016/0190-9622(93)70023-m.
As part of a military study of the natural history of human immunodeficiency virus type 1 (HIV-1) disease, all patients entered in the study were examined for cutaneous changes associated with HIV-1 infection.
Our purpose was to characterize and record the types of inflammatory dermatoses in a large number of HIV-1-infected patients to determine whether there was a correlation with the stage of disease.
The clinical findings in each case were compared with the results of cultures and biopsy specimens and correlated with Walter Reed stage.
Most of the inflammatory dermatoses were maculopapular eruptions often with prominent follicular involvement, and in some there was a lichenoid component. With increasing Walter Reed stage, many eruptions become papulosquamous, some with psoriasiform scale and some with a hypertrophic lichenoid appearance.
Although most of the inflammatory eruptions were nonspecific clinically, most cases showed features resembling those in graft-versus-host disease.
作为一项关于人类免疫缺陷病毒1型（HIV-1）疾病自然史的军事研究的一部分，对所有参与该研究的患者进行了与HIV-1感染相关的皮肤变化检查。
我们的目的是对大量HIV-1感染患者的炎症性皮肤病类型进行特征描述和记录，以确定其与疾病阶段是否存在相关性。
将每个病例的临床发现与培养结果和活检标本进行比较，并与沃尔特·里德分期相关联。
大多数炎症性皮肤病为斑丘疹，常伴有明显的毛囊受累，部分病例有苔藓样成分。随着沃尔特·里德分期增加，许多皮疹变为丘疹鳞屑性，一些有银屑病样鳞屑，一些有肥厚性苔藓样外观。
尽管大多数炎症性皮疹在临床上是非特异性的，但大多数病例表现出与移植物抗宿主病相似的特征。
