Smith K J, Skelton H G, Yeager J, Angritt P, Wagner K F
Department of Dermatopathology, Armed Forces Institute of Pathology, Bethesda, Maryland.
J Am Acad Dermatol. 1993 Mar;28(3):470-6. doi: 10.1016/0190-9622(93)70070-a.
Within a large population of patients seropositive for human immunodeficiency virus type 1 (HIV-1), seven had biopsy specimens that showed foreign body reactions with histologic features different from those seen in non-HIV-1-positive patients.
These cases were reviewed to determine whether there was a specific pattern of response to foreign bodies in HIV-1 infection and whether this pattern was related to the stage of disease.
Biopsy specimens were reviewed to identify ruptured epidermal cysts. These were studied in routine hematoxylin-and-eosin-stained sections and with immunohistochemical stains to characterize the inflammatory infiltrate.
The lesions in HIV-1-infected patients contained abundant macrophages with evidence of decreased function and a lack of giant cells.
These histologic features suggest an early functional deficit before there is a significant decrease in the number of T4 lymphocytes.
在一大群1型人类免疫缺陷病毒（HIV-1）血清阳性患者中，有7例患者的活检标本显示出异物反应，其组织学特征与非HIV-1阳性患者所见不同。
对这些病例进行回顾，以确定HIV-1感染中对异物的反应是否存在特定模式，以及这种模式是否与疾病阶段相关。
对活检标本进行复查以识别破裂的表皮囊肿。在常规苏木精-伊红染色切片中对其进行研究，并使用免疫组织化学染色来表征炎性浸润。
HIV-1感染患者的病变中含有大量巨噬细胞，有功能下降的证据且缺乏巨细胞。
这些组织学特征表明在T4淋巴细胞数量显著减少之前就存在早期功能缺陷。
